Evidence map›Paper›PMID 30256416›Full record

ArticleJournal of medical primatology2018

Multiple endocrine neoplasia-like syndrome in 24 baboons (Papio spp.).

Alexandra Confer, Michael A Owston, Shyamesh Kumar, Edward J Dick

Abstract readCase Reports
In one paragraph

Article in Journal of medical primatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alexandra ConferSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.
Michael A OwstonSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.
Shyamesh KumarSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.ORCID 0000-0001-9261-2263
Edward J DickSouthwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.
Texas Biomedical Research Institute · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
WNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GOLDBERG, ERWIN · 1999 to 2011
$79.1M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR016228 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 2001 to 2001
$1.9M
NCRR NIH HHS C06 RR016228NCRR NIH HHS P51 RR013986NIH HHS P51 OD011133
6 · The paper itself

Abstract

Multiple endocrine neoplasia (MEN) has not been reported in baboons, but this condition is well described in humans. An internal database was searched for all cases of concurrent endocrine hyperplasia and neoplasia in baboons. Twenty-four baboons (Papio spp.) with concurrent endocrine hyperplasia and neoplasia were identified. Twenty-one baboons had lesions in two endocrine organs, two baboons had lesions in three organs, and one baboon had lesions in four organs. Ten baboons aligned with the MEN1 classification; 14 baboons did not match any current human MEN classification. We report 24 cases of MEN-like syndrome in baboons. MEN1-like lesions accounted for nearly half (41%) of the affected animals. Genetic analysis of baboons with MEN-like syndrome could further elucidate the mechanisms of MEN and support the use of baboons as animal models for human MEN.

Indexed as

PapioAnimalsAnimals, LaboratoryFemaleMaleMonkey DiseasesMultiple Endocrine NeoplasiaRetrospective StudiesSyndromeTexasadrenal gland neoplasmspancreatic neoplasmspituitary neoplasmsprimatethyroid neoplasms

Identifiers

PMID30256416
PMCPMC6234079
OpenAlexW2890402070

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.