Evidence map›Paper›PMID 30255987›Full record

ArticleStem cells translational medicine2018

Higher Pericyte Content and Secretory Activity of Microfragmented Human Adipose Tissue Compared to Enzymatically Derived Stromal Vascular Fraction.

Bianca Vezzani, Isaac Shaw, Hanna Lesme, Li Yong, Nusrat Khan, Carlo Tremolada, Bruno Péault

3 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 78 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 4 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03913910 unknown statusnot on this mapstarted 2019, after this paper: background citation

Treatment of Perianal Fistulas Through Injection of Autologous and Micro-fragmented Adipose Tissue: a Prospective Multicentre Study

TypeobservationalSponsorAzienda Ospedaliero, Universitaria PisanaRan2019 to 2020Enrolled100ConditionsPerianal FistulaArmsLipogems
NCT04326907 nacompletednot on this map

Efficacy and Safety of Treatment of Complex Anal Fistulas Not Associated With Crohn's Disease Using Centrifuged Adipose Tissue Containing Progenitor Cells: a Randomized Controlled Clinical Trial

TypeinterventionalSponsorUniversity Hospital of FerraraRan2016 to 2019Enrolled120ConditionsAnal FistulaArmsAutologous centrifuged adipose tissue (CAT) injection after anal fistulectomy
NCT07121556 narecruitingnot on this mapstarted 2025, after this paper: background citation

Randomized Double- Blind Study on the Treatment of Symptomatic Bilateral Knee Osteoarthritis: Intra-articular Injection of Autologous Microfragmented Adipose Tissue and Hyaluronic Acid vs Intra Articular Injection of Autologous Microfragmented Adipose Tissue. Double-Blind Randomized Controlled Clinical Trial

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2025 to 2030Enrolled100ConditionsOsteoarthritis Knees BothArmsMFAT + HA left knee - MFAT + placebo right knee, MFAT + HA right knee - MFAT + placebo left knee
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 4 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  4. Comparing mechanical and enzymatic isolation procedures to isolate adipose-derived stromal vascular fraction: A systematic review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Bianca VezzaniMRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-5869-6301
Isaac ShawMRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Hanna LesmeMRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Li YongMRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Nusrat KhanMRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Carlo TremoladaImage Institute, Milan, Italy.
Bruno PéaultMRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.
University of Edinburgh · GBMRC Centre for Regenerative Medicine · GBImaginary (Italy) · ITUniversity of California, Los Angeles · US

Funding

British Heart FoundationMedical Research Council G1000816
6 · The paper itself

Abstract

Autologous adipose tissue is used for tissue repletion and/or regeneration as an intact lipoaspirate or as enzymatically derived stromal vascular fraction (SVF), which may be first cultured into mesenchymal stem cells (MSCs). Alternatively, transplant of autologous adipose tissue mechanically fragmented into submillimeter clusters has recently showed remarkable efficacy in diverse therapeutic indications. To document the biologic basis of the regenerative potential of microfragmented adipose tissue, we first analyzed the distribution of perivascular presumptive MSCs in adipose tissue processed with the Lipogems technology, observing a significant enrichment in pericytes, at the expense of adventitial cells, as compared to isogenic enzymatically processed lipoaspirates. The importance of MSCs as trophic and immunomodulatory cells, due to the secretion of specific factors, has been described. Therefore, we investigated protein secretion by cultured adipose tissue clusters or enzymatically derived SVF using secretome arrays. In culture, microfragmented adipose tissue releases many more growth factors and cytokines involved in tissue repair and regeneration, noticeably via angiogenesis, compared to isogenic SVF. Therefore, we suggest that the efficient tissue repair/regeneration observed after transplantation of microfragmented adipose tissue is due to the secretory ability of the intact perivascular niche. Stem Cells Translational Medicine 2018;7:876-886.

Indexed as

Abdominal FatAdipose TissueAdultAgedAgglutininsAngiogenic ProteinsCollagenasesCytokinesFemaleFlow CytometryHumansIntercellular Signaling Peptides and ProteinsMiddle AgedPericytesProteomeAgglutininsAngiogenic ProteinsCollagenasesCytokinesIntercellular Signaling Peptides and ProteinsProteomeAdipose stem cellCytokineMesenchymal stem cellPericyteSecretome

Identifiers

PMID30255987
PMCPMC6265639
OpenAlexW2893139531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.