Evidence map›Paper›PMID 30255936›Full record

ArticleThe Journal of comparative neurology2018

Regional vesicular acetylcholine transporter distribution in human brain: A [

Roger L Albin, Nicolaas I Bohnen, Martijn L T M Muller, William T Dauer, Martin Sarter, Kirk A Frey, Robert A Koeppe

Abstract read
In one paragraph

Article in The Journal of comparative neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. A lifespan staging model of basal forebrain cholinergic vulnerability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  5. Article
  6. Cellular and molecular associations with intrinsic brain organization.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Brain cholinergic terminal density utilizing [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. PET Quantification of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Roger L AlbinNeurology Service & GRECC, VAAAHS, Ann Arbor, Michigan.ORCID 0000-0002-0629-608X
Nicolaas I BohnenNeurology Service & GRECC, VAAAHS, Ann Arbor, Michigan.
Martijn L T M MullerUniversity of Michigan Morris K. Udall Center of Excellence for Research in Parkinson's Disease, Ann Arbor, Michigan.
William T DauerNeurology Service & GRECC, VAAAHS, Ann Arbor, Michigan.
Martin SarterUniversity of Michigan Morris K. Udall Center of Excellence for Research in Parkinson's Disease, Ann Arbor, Michigan.
Kirk A FreyDepartment of Neurology, University of Michigan, Ann Arbor, Michigan.
Robert A KoeppeUniversity of Michigan Morris K. Udall Center of Excellence for Research in Parkinson's Disease, Ann Arbor, Michigan.

Funding

Tomography and Data AnalysisP01NS015655 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 1985 to 2012
$13.0M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Cholinergic Interneurons in Tourette SyndromeR21NS088302 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2015
$427k
NINDS NIH HHS P01 NS015655NINDS NIH HHS P50 NS091856NINDS NIH HHS R21 NS088302
6 · The paper itself

Abstract

Prior efforts to image cholinergic projections in human brain in vivo had significant technical limitations. We used the vesicular acetylcholine transporter (VAChT) ligand [

Indexed as

Brain ChemistryAdultAgedAged, 80 and overAgingBrainBrain MappingFemaleHealthy VolunteersHumansMagnetic Resonance ImagingMaleMiddle AgedParasympathetic Nervous SystemPiperidinesPositron-Emission Tomographyfluoroethoxy-benzovesamicolPiperidinesRadiopharmaceuticalsSLC18A3 protein, humanVesicular Acetylcholine Transport Proteinsacetylcholineagingbasal forebraincerebellumpedunculopontine nucleusRRID: SCR_001847RRID: SCR_007037striatumthalamus

Identifiers

PMID30255936
PMCPMC6827569

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.