ArticleJournal of psychopharmacology (Oxford, England)2018
The moderating effect of psychedelics on the prospective relationship between prescription opioid use and suicide risk among marginalized women.
Article in Journal of psychopharmacology (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Self-inflicted transorbital intracranial foreign body following ingestion of hallucinogenic psilocybin mushrooms.American journal of ophthalmology case reports · 2025Article
- The molecular mechanisms through which psilocybin prevents suicide: evidence from network pharmacology and molecular docking analyses.Translational psychiatry · 2025Article
- Race and Gender Differences in the Moderating Relationship of Psychedelics on Stigma and Distress.Psychedelic medicine (New Rochelle, N.Y.) · 2025Article
- Psychedelics and Suicide-Related Outcomes: A Systematic Review.Journal of clinical medicine · 2025Review
- Pain, impairment, medication use and health-related quality of life of retired professional rugby players.South African journal of sports medicine · 2024Article
- Longitudinal and transcultural assessment of the relationship between hallucinogens, well-being, and post-traumatic growth during the COVID-19 pandemic.Scientific reports · 2023Article
- Hallucinogenic potential: a review of psychoplastogens for the treatment of opioid use disorder.Frontiers in pharmacology · 2023Review
- Race and ethnicity moderate the associations between lifetime psychedelic use (MDMA and psilocybin) and psychological distress and suicidality.Scientific reports · 2022Article
- Interest in receiving psychedelic-assisted therapy among marginalized women: Implications and findings from a community-based study in Canada.Drug and alcohol dependence reports · 2022Article
- Using Mindfulness-Based Cognitive Therapy to Prevent Suicide among High Suicide Risk Patients who also Misuse Opioids: A Preliminary Probe of Feasibility and Effectiveness.International journal of mental health and addiction · 2022Article
- Psychedelic use is associated with reduced daily opioid use among people who use illicit drugs in a Canadian setting.The International journal on drug policy · 2022Article
- Factors Influencing Brucellosis Preventive Behaviors among Marginalized Iranian Women: An Application of the Health Belief Model.TheScientificWorldJournal · 2022Article
- Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders.Current addiction reports · 2022Review
- Suicidal Behavior and Club Drugs in Young Adults.Brain sciences · 2021Article
- On the Relationship between Classic Psychedelics and Suicidality: A Systematic Review.ACS pharmacology & translational science · 2021Review
- Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential?Frontiers in psychiatry · 2021Article
- People of color in North America report improvements in racial trauma and mental health symptoms following psychedelic experiences.Drugs (Abingdon, England) · 2021Article
- The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial.Frontiers in pharmacology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsGiven high rates of depression and suicide among marginalized women, and increasing calls to integrate trauma-informed biomedical and community-led structural interventions, this study longitudinally examines the potential moderating effect of psychedelic use on the relationship between other illicit drug use and suicide risk.
methodsData (2010-2017) were drawn from a community-based, prospective open cohort of marginalized women in Vancouver, Canada. Extended Cox regression analyses examined the moderating effect of psychedelic use on the association between other illicit drug use and incidence of suicidal ideation or attempt over follow-up.
resultsOf 340 women without suicidal ideation or attempt at baseline, 16% ( n=53) reported a first suicidal episode during follow-up, with an incidence density of 4.63 per 100 person-years (95% confidence interval 3.53-6.07). In unadjusted analysis, psychedelic use moderated the relationship between prescription opioid use and suicide risk: among women who did not use psychedelics, prescription opioid use increased the hazard of suicide (hazard ratio 2.91; 95% confidence interval 1.40-6.03) whereas prescription opioid use was not associated with increased suicidal ideation or attempt among those who used psychedelics (hazard ratio 0.69; 95% confidence interval 0.27-1.73) (interaction term p-value: 0.016). The moderating effect of psychedelics remained significant when adjusted for confounders (interaction term p-value: 0.036).
conclusionsPsychedelic use had a protective moderating effect on the relationship between prescription opioid use and suicide risk. In the context of a severe public health crisis around prescription opioids and lack of addiction services tailored to marginalized women, this study supports calls for innovative, evidence-based and trauma-informed interventions, including further research on the potential benefits of psychedelics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.