Evidence map›Paper›PMID 30255622›Full record

ArticleJournal of cellular and molecular medicine2018

Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2.

Zhengbo Shao, Jie Wu, Guoqing Du, Huifang Song, Shu-Hong Li, Sheng He, Jiao Li, Jun Wu, Richard D Weisel, Huiping Yuan and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Young Sca-1Journal of nanobiotechnology · 2023
    Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Zhengbo ShaoDepartment of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jie WuDepartment of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Guoqing DuDepartment of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Huifang SongDivision of Cardiovascular Surgery, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Shu-Hong LiDivision of Cardiovascular Surgery, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Sheng HeDivision of Cardiovascular Surgery, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Jiao LiDivision of Cardiovascular Surgery, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Jun WuDivision of Cardiovascular Surgery, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Richard D WeiselDivision of Cardiovascular Surgery, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.
Huiping YuanDepartment of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Ren-Ke LiDivision of Cardiovascular Surgery, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-8584-5736
University Health Network · CAHarbin Medical University · CN

Funding

CIHR 143323
6 · The paper itself

Abstract

Retinal ganglion cell apoptosis and optic nerve degeneration are prevalent in aged patients, which may be related to the decrease in bone marrow (BM) stem cell number/function because of the possible cross-talk between the two organs. This pathological process is accelerated by retinal ischaemia-reperfusion (I/R) injury. This study investigated whether young BM stem cells can regenerate and repair the aged retina after acute I/R injury. Young BM stem cell antigen 1 positive (Sca-1

Indexed as

Stem Cell TransplantationAgingAnimalsAntigens, LyApoptosisBone Marrow CellsBone Marrow TransplantationFibroblast Growth Factor 2Gene Expression Regulation, DevelopmentalHumansMembrane ProteinsMiceOptic NerveReperfusion InjuryRetinaRetinal Ganglion CellsAntigens, LyFibroblast Growth Factor 2Ly6a protein, mouseMembrane Proteinsagingretinal ischaemia-reperfusionretinal regenerationstem cell homing

Identifiers

PMID30255622
PMCPMC6237572
OpenAlexW2893866020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.