Evidence map›Paper›PMID 30255621›Full record

ArticleClinical implant dentistry and related research2018

Titanium as a modifier of the peri-implant microbiome structure.

Diane Daubert, Alexander Pozhitkov, Jeffrey McLean, Georgios Kotsakis

Abstract read
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In one paragraph

Article in Clinical implant dentistry and related research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Diane DaubertDepartment of Periodontics, Clinical and Periodontal Research Laboratory, University of Washington, Seattle, WA (Washington), USA.ORCID https://orcid.org/0000-0002-7307-4102
Alexander PozhitkovDepartment of Restorative Dentistry, University of Washington, Seattle, WA (Washington), USA.
Jeffrey McLeanDepartment of Periodontics and Oral Health Sciences, University of Washington, Seattle, WA (Washington), USA.
Georgios KotsakisDepartment of Periodontics, Clinical and Periodontal Research Laboratory, University of Washington, Seattle, WA (Washington), USA.

Funding

Domestication and characterization of TM7-the most elusive oral phylumR01DE023810 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xuesong He, Jeffrey Scott McLean · 2014 to 2026
$6.6M
National Institute of Dental and Craniofacial Research RO1DE023810NIDCR NIH HHS R01 DE023810Universtiy of Washington School of Dentistry Elam M. and Georgina E. Hack Memorial Research Fund
6 · The paper itself

Abstract

backgroundRecent data support the implication of accelerated titanium dissolution products in peri-implantitis. It is unknown whether these dissolution products have an effect on the peri-implant microbiome, the target of existing peri-implantitis therapies. PURPOSE: This study assessed the relationship between the peri-implant microbiome, dissolved titanium levels, and peri-implantitis. MATERIALS AND

methodsClinical, microbiome, and titanium data were collected from a periodontal population having implants in function for 10 years. Clinical examinations were performed, and submucosal plaque samples were collected from the deepest site per implant. An aliquot of the sample was used for 16S rRNA gene sequencing, with the remainder analyzed for titanium quantity using mass spectrometry. Sequences were clustered into taxonomic units at 97% minimum sequence similarity using the QIIME pipeline approach.

resultsFifteen implants were assessed. According to established case definitions, six had a diagnosis of peri-implantitis; nine were healthy. The genera Streptococcus, Prevotella and Haemophilus characterized peri-implant health. Peri-implantitis was associated with a marked increase in Veillonella. Quantities of dissolved titanium were identified in 40% of sites. Titanium presence was associated with peri-implant disease status (P = .02) and correlated to the first principal component of the microbiome (rho = 0.552) and its alpha-diversity (rho = -0.496). Canonical correlation analyses found that titanium levels, but not health or disease status of the implant, were significantly associated with the microbiota composition (P = .045).

conclusionsThese findings suggest an association between titanium dissolution products and peri-implantitis and support a role for these products in modifying the peri-implant microbiome structure and diversity.

Indexed as

AgedAged, 80 and overCross-Sectional StudiesDental PlaqueFemaleHumansMaleMicrobiotaMiddle AgedPeri-ImplantitisPeriodontitisSequence Analysis, RNATitaniumVeillonellaTitaniumbacteriacorrosiondental implantmicrobiomeperi-implantitistitanium

Identifiers

PMID30255621
PMCPMC6283679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.