ArticleJournal of child psychology and psychiatry, and allied disciplines2018
Longitudinal structural brain development and externalizing behavior in adolescence.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review.Biological psychiatry · 2024Pooled it
- Parental Deprivation- and Threat-Based Factors Associated with Youth Emotion-Based Neurocircuitry and Externalizing Behavior: A Systematic Review.Research on child and adolescent psychopathology · 2024Pooled it
- Brain controllability mediates the effects of early life adversity on adolescent behavior and cognition moderated by genetic risks.Research square · 2026Article
- Aggressiveness that makes one grow: a destructive or vital force in adolescence? Reflections and working hypotheses.Frontiers in behavioral neuroscience · 2026Article
- Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12-Wave Neuroimaging Study.Human brain mapping · 2025Article
- Exploring Emotional Dysregulation and Avoidance with Caregivers as the Mechanisms Linking Social Communication Understanding and Aggressive Behaviours.Journal of autism and developmental disorders · 2025Article
- Hippocampal subregion volumes and preadolescent depression risk in the ABCD sample.Journal of affective disorders · 2025Article
- Facets of trait impulsivity and their relationships to developmental trajectories of externalizing behaviors from childhood into early adolescence.Journal of research in personality · 2025Article
- Unpacking socio-demographic predictors of child aggression: insights from a Saudi Arabian context from parents' and caregivers' perspectives.Frontiers in psychology · 2025Article
- Can socioeconomic status moderate the effect of a conflictive family environment on brain structure and externalizing/internalizing behavior in children and adolescents?Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Development of Self-Concept in Childhood and Adolescence: How Neuroscience Can Inform Theory and Vice Versa.Human development · 2024Article
- Mood variability during adolescent development and its relation to sleep and brain development.Scientific reports · 2024Article
- An epidemiological study of season of birth, mental health, and neuroimaging in the UK Biobank.PloS one · 2024Article
- Body, image, and digital technology in adolescence and contemporary youth culture.Frontiers in psychology · 2024Review
- Are concepts of adolescence from the Global North appropriate for Africa? A debate.BMJ global health · 2023Article
- Stage 2 Registered Report: The Bidirectional Relationship Between Brain Features and the Dysregulation Profile: A Longitudinal, Multimodal Approach.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Article
- Brain Structure Relations With Psychopathology Trajectories in the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Associations Between Adolescent Pain and Psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study.Behavior genetics · 2023Article
- Adolescent Distress: Is There a Vaccine? Social and Cultural Considerations during the COVID-19 Pandemic.International journal of environmental research and public health · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCross-sectional studies report relations between externalizing behavior and structural abnormalities in cortical thickness of prefrontal regions and volume reductions in subcortical regions. To understand how these associations emerge and develop, longitudinal designs are pivotal.
methodIn the current longitudinal study, a community sample of children, adolescents and young adults (N = 271) underwent magnetic resonance imaging (MRI) in three biennial waves (680 scans). At each wave, aspects of externalizing behavior were assessed with parent-reported aggression and rule-breaking scores (Child Behavior Checklist), and self-reported aggression scores (Buss-Perry Aggression Questionnaire). Regions of interest (ROIs) were selected based on prior research: dorsolateral prefrontal (dlPFC), orbitofrontal (OFC), anterior cingulate cortex (ACC), insula, and parahippocampal cortex, as well as subcortical regions. Linear mixed models were used to assess the longitudinal relation between externalizing behavior and structural brain development. Structural covariance analyses were employed to identify whether longitudinal relations between ROIs (maturational coupling) were associated with externalizing behavior.
resultsLinear mixed model analyses showed a negative relation between parent-reported aggression and right hippocampal volume. Moreover, this longitudinal relation was driven by change in hippocampal volume and not initial volume of hippocampus at time point 1. Exploratory analyses showed that stronger maturational coupling between prefrontal regions, the limbic system, and striatum was associated with both low and high externalizing behavior.
conclusionsTogether, these findings reinforce the hypothesis that altered structural brain development coincides with development of more externalizing behavior. These findings may guide future research on normative and deviant development of externalizing behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.