Evidence map›Paper›PMID 30255487›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2018

Does fatigue in Parkinson's disease correlate with autonomic nervous system dysfunction?

Enrica Olivola, Livia Brusa, Camilla Rocchi, Orazio Schillaci, Claudio Liguori, Rocco Cerroni, Mariangela Pierantozzi, Agostino Chiaravalloti, Alessandro Stefani, Fabrizio Stocchi

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Research progress of chronic fatigue in neurodegenerative diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  2. Review
  3. Review
  4. Article
  5. Clinical characteristics and hemodynamic responses to head-up tilt test in children and adolescents with unexplained sighing.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  6. Article
  7. Article
  8. Association between fatigue and motor progression in Parkinson's disease in southern Chinese.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Enrica OlivolaUOSD Parkinson's Center, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford, 81, 00133, Rome, Italy.
Livia BrusaOspedale S. Eugenio, ASL RMC, Rome, Italy.
Camilla RocchiUOSD Parkinson's Center, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford, 81, 00133, Rome, Italy.
Orazio SchillaciIRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli, Italy.
Claudio LiguoriUOSD Parkinson's Center, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford, 81, 00133, Rome, Italy.
Rocco CerroniUOSD Parkinson's Center, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford, 81, 00133, Rome, Italy.
Mariangela PierantozziUOSD Parkinson's Center, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford, 81, 00133, Rome, Italy.
Agostino ChiaravallotiIRCCS Istituto Neurologico Mediterraneo (INM) Neuromed, Pozzilli, Italy.
Alessandro StefaniUOSD Parkinson's Center, Department of Systems Medicine, University of Rome "Tor Vergata", Viale Oxford, 81, 00133, Rome, Italy. stefani@uniroma2.it.ORCID http://orcid.org/0000-0002-1806-8922
Fabrizio StocchiDepartment of Neurology, Institute for Research and Medical Care, IRCCS San Raffaele, Rome, Italy.
University of Rome Tor Vergata · ITSt. Eugenio Hospital · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite its negative impact on quality of life, fatigue in Parkinson's disease (PD) remains an under-recognized issue and the underlying pathology is undetermined.

objectiveTo contribute at understanding the pathogenesis of fatigue in a naturalistic cohort of cognitively intact PD patients.

methodsIn a Caucasian population of PD patients (n = 27), we evaluated to what extent fatigue (quantified as PFS-16 score) is associated with PD duration and with autonomic dysfunction, studied by both MIBG scintigraphy and autonomic nervous system testing. The latter included the head-up tilt test, Valsalva maneuver, deep breathing, and handgrip tests.

resultsPFS-16 score correlated with disease duration (R = 0.57, p = 0.002). Fatigue showed a clear correlation with deep breathing test (R = - 0.53, p = 0.004) but not with the MIBG H/M ratios.

conclusionsOur data are consistent with a multifactorial pathogenesis of fatigue and with effects of dopamine depletion in PD-related fatigue; on the other hand, our findings do not support a role for sympathetic denervation in PD-related fatigue.

Indexed as

Correlation of DataAgedAutonomic Nervous System DiseasesCohort StudiesFatigueFemaleHumansMaleMental Status ScheduleMiddle AgedParkinson DiseaseSeverity of Illness IndexWhite PeopleAutonomic nervous systemFatigueMyocardial scintigraphyParkinson’s disease

Identifiers

PMID30255487
OpenAlexW2893588366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.