ArticleRheumatology and therapy2018
Clinical and Immunological Features of Anti-centromere Antibody-Positive Primary Sjögren's Syndrome.
Article in Rheumatology and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Salivary gland SPECT/CT of parotid glands in patients with lymphoepithelial sialadenitis: preliminary study on clinical and pathological features.Oral radiology · 2026Article
- Anti-centromere antibody positivity: a spectrum of clinical diagnoses and immunological patterns in a large patient cohort.Clinical rheumatology · 2026Article
- Non-Conventional and Emerging Autoantibodies in Sjögren's Disease.Journal of inflammation research · 2026Review
- Identifying the clinical signature of anti-centromere antibody-positive Sjögren's syndrome: a machine learning-based analysis of a multicenter cohort.Frontiers in immunology · 2026Article
- Anti-centromere protein B antibody positivity in primary Sjögren's disease: clinical features and prognostic implications.Frontiers in immunology · 2026Article
- Article
- Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjögren's disease reveals common and distinct immune activation and fibroblast-mediated inflammation.Nature communications · 2025Article
- Case of successful treatment with glucocorticoid for isolated anti-centromere antibody-positive acute interstitial nephritis.CEN case reports · 2025Article
- Article
- Should We Adopt Increased Dilutions for Indirect Immunofluorescence in Pediatric Anti-Centromere Antibody Testing? Insights from a Three-Year Retrospective Study.Children (Basel, Switzerland) · 2024Article
- Successful Immunosuppressive Therapy for Interstitial Lung Disease Associated with Sjögren's Syndrome with Double-positive Anti-SS-A and Anti-centromere Antibodies.Internal medicine (Tokyo, Japan) · 2024Article
- Ultrasound shear wave elastography for assessing minor salivary gland involvement in anti-centromere antibody-positive primary Sjögren's syndrome: a retrospective study.Clinical and experimental medicine · 2024Review
- Anti-centromere antibody positivity is an independent variable associated with salivary gland ultrasonography score in Sjögren's syndrome.Scientific reports · 2024Article
- [Clinical and immunological features of primary Sjögren's syndrome patients with positive anti-centromere protein B antibody].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Is the anti-centromere antibody a marker for a distinct subset of polyautoimmunity in Sjögren's syndrome?The Korean journal of internal medicine · 2021Article
- Clinical influences of anticentromere antibody on primary Sjögren's syndrome in a prospective Korean cohort.The Korean journal of internal medicine · 2021Article
- Clinical features and risk factors of Raynaud's phenomenon in primary Sjögren's syndrome.Clinical rheumatology · 2021Article
- Pulmonary amyloidosis and cystic lung disease in primary Sjögren's syndrome: a case report and literature review.Clinical rheumatology · 2021Review
- Brainstem auditory evoked potentials in patients with primary Sjögren's syndrome without central nervous system involvement.Clinical rheumatology · 2021Article
- Ultrasonographic characteristics of major salivary glands in anti-centromere antibody-positive primary Sjögren's syndrome.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAnti-centromere antibody (ACA)-positive Sjögren's syndrome (SS) is considered a subtype of SS. ACA-positive SS patients display several features, such as Raynaud's phenomenon, sclerodactyly, and extraglandular dysfunction. However, information on the features of ACA-positive SS is insufficient and the clinical significance of ACA in SS has not been fully established. The aim of this study was to clarify the features of ACA-positive SS.
methodsAll patients with primary SS who visited our hospital were enrolled. Clinical information and immunological tests were collected and statistically analyzed.
resultsA total of 585 patients were classified as having primary SS. They were divided into four groups by serum ACA and anti-SS-A antibody status as follows: 22 had ACA only (ACA alone), 464 had anti-SS-A antibodies only (SS-A alone), 26 had both ACA and anti-SS-A antibodies (double-positive), and 73 had neither ACA nor anti-SS-A antibodies (seronegative). The proportion of patients with dryness did not differ between the four groups. The proportion of patients with Raynaud's phenomenon or sclerodactyly was higher in the ACA alone and double-positive groups. The proportion of patients with increased serum IgG or IgA was 0 and 5% in the ACA alone group, 61 and 20% in the SS-A alone group, 52 and 28% in the double-positive group, and 20 and 4% in the seronegative group (p < 0.01 and p < 0.01), respectively. The proportion of patients with leukocytopenia was significantly lower in the SS-A-negative group than in the other groups.
conclusionsOur study identified characteristics of ACA-positive SS patients that differ from those of anti-SS-A antibody-positive SS patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.