ArticleBotanical studies2018
Arabidopsis and rice showed a distinct pattern in ZIPs genes expression profile in response to Cd stress.
Article in Botanical studies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 96 citations in OpenAlex.
- GsIRT3: a zinc-iron transporter gene from Glycine soja, enhancing alkali stress tolerance in Arabidopsis thaliana.Journal of plant research · 2026Article
- Transcription Factor TCP9 EnhancesPlants (Basel, Switzerland) · 2026Article
- Molecular insights into cadmium transport and micronutrient crosstalk in rice: Towards minimizing grain Cd.Journal of integrative plant biology · 2026Review
- Four ZIPs contribute to Zn, Fe, Cu and Mn acquisition at the outer root domain.PLoS genetics · 2025Article
- Selenium Alleviates Cadmium Toxicity by Regulating Carbon Metabolism, AsA-GSH Cycle, and Cadmium Transport inPlants (Basel, Switzerland) · 2025Article
- Review
- Exploring genotypic variation and gene expression associated to cadmium accumulation in bread wheat.Scientific reports · 2024Article
- The Uptake, Transfer, and Detoxification of Cadmium in Plants and Its Exogenous Effects.Cells · 2024Review
- An integration of genome-wide survey, homologous comparison and gene expression analysis provides a basic framework for the ZRT, IRT-like protein (ZIP) in foxtail millet.Frontiers in plant science · 2024Article
- Exogenous plant growth regulator and foliar fertilizers for phytoextraction of cadmium with Boehmeria nivea [L.] Gaudich from contaminated field soil.Scientific reports · 2023Article
- The Effect of Cadmium on Plants in Terms of the Response of Gene Expression Level and Activity.Plants (Basel, Switzerland) · 2023Review
- Cadmium accumulation regulated by a rice heavy-metal importer is harmful for host plant and leaf bacteria.Journal of advanced research · 2023Article
- Temperature Dependence of Metals Accumulation and Removal Kinetics byPlants (Basel, Switzerland) · 2023Article
- Temporal Comparative Transcriptome Analysis on Wheat Response to Acute Cd Toxicity at the Seedling Stage.Plants (Basel, Switzerland) · 2023Article
- Genetic Regulation Mechanism of Cadmium Accumulation and Its Utilization in Rice Breeding.International journal of molecular sciences · 2023Review
- Cloning and Functional Characterization ofGenes · 2022Article
- Metalloprotein-Specific or Critical Amino Acid Residues: Perspectives on Plant-Precise Detoxification and Recognition Mechanisms under Cadmium Stress.International journal of molecular sciences · 2022Review
- Physiological and Transcriptomic Comparison of Two Sunflower (Frontiers in plant science · 2022Article
- Article
- Advances in molecular mechanisms underlying cadmium uptake and translocation in rice.Frontiers in plant science · 2022Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPlant ZIP genes represent an important transporter family involved in metal transport. Evidence has implied that some ZIPs may contribute to plant Cd uptake, but a genome-wide examination of ZIPs' role in Cd tolerance and uptake has rarely been reported. In this study, a genome-wide bioinformatic screening of candidate ZIP genes in Arabidopsis and rice was performed, followed by a systematic determination of their expression profile in response to Cd stress. Typical up-regulated ZIPs genes were then expressed in yeast cells to examine their effect on hosts' Cd uptake.
resultsA total of 27 ZIP genes in Arabidopsis and rice were screened out based on sequence similarity. In Arabidopsis, Cd exposure strongly impacted the expression of most ZIPs, among which AtIRT1, AtIRT2, AtIRT4 AtZIP9, AtZIP10 and AtZIP12 were sharply up-regulated and AtIRT3, AtIRT5 were significantly down-regulated in root. In rice, all tested genes in shoot except for OsIRT1 and OsIRT12 were sharply up-regulated, while OsIRT1 and OsZIP1 in root were significantly down-regulated. Interestingly, some genes like AtIRT3, AtZIP5, AtZIP12, OsIRT1 and OsZIP1 showed converse expression regulation when subject to the tested Cd stress. When expressed in yeast cells, three ZIPs, AtIRT1, OsZIP1 and OsZIP3, caused a substantial increase in Cd sensitivity and Cd accumulation of the host cells.
conclusionsIn conclusion, this study revealed a distinct pattern in ZIPs family genes expression between Arabidopsis and rice in response to Cd stress. Arabidopsis mainly up-regulated root ZIPs genes, while rice mainly up-regulated shoot ZIPs genes. Three genes, AtIRT1, OsZIP1 and OsZIP3, conferred an increased Cd accumulation and sensitivity to Cd stress when expressed in yeast cells, further implying their roles in Cd uptake in plants.
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