SynthesisAdvances in therapy2018
The Association Between Overactive Bladder and Falls and Fractures: A Systematic Review.
Synthesis in Advances in therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07738354 (Construction, Validation, and Demonstration of a Comprehensive Prevention, Treatment, and Rehabilitation System for Toileting-Related Falls in Older Adults and People With Disabilities), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Construction, Validation, and Demonstration of a Comprehensive Prevention, Treatment, and Rehabilitation System for Toileting-Related Falls in Older Adults and People With Disabilities
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Pooled it
- Randomized trial of transcutaneous tibial nerve stimulation to treat overactive bladder in older women.PloS one · 2026Trial
- Pelvic floor muscle training, the risk of falls and urgency urinary incontinence in older women.Zeitschrift fur Gerontologie und Geriatrie · 2022Trial
- An Integrated Prevention, Treatment, and Rehabilitation Program for Toileting-Related Falls in Older Adults and People with Disabilities: The Protocol for a Multicenter Prospective Single-Arm Implementation Study.Healthcare (Basel, Switzerland) · 2026Article
- Management of Persistent Storage Symptoms and Overactive Bladder in Men Diagnosed with Benign Prostatic Hyperplasia: A Narrative Review.Advances in therapy · 2026Review
- Treatment Persistence and Adherence with Overactive Bladder Medications in Taiwan: A Retrospective Database Analysis.European urology open science · 2026Article
- Chemodenervation Use for Overactive Bladder in Female Medicare Beneficiaries.Urogynecology (Philadelphia, Pa.) · 2026Article
- Association of Overactive Bladder With Fall Risk Among US Adults Aged 20-69 Years.Neurourology and urodynamics · 2026Article
- Association of overactive bladder with all-cause and cardiovascular mortality in women: A propensity-matched NHANES study.BJUI compass · 2025Article
- Satisfaction and persistence with vibegron in the first 6 months of overactive bladder treatment: interim results of the phase 4, real-world COMPOSUR study.BMC urology · 2025Observational
- Nocturia and Nighttime Falls in Older Adults With Hip Fractures: A Retrospective Observational Study.Geriatric orthopaedic surgery & rehabilitation · 2025Article
- Benign Prostatic Hyperplasia and the Risk of Falls in Older Men: Insights From a Population-Based Study on Geriatric Morbid Conditions.International neurourology journal · 2024Article
- Use of overactive bladder anticholinergic medications associated with falls leading to emergency department visits: results from the ADRED study.European journal of clinical pharmacology · 2023Article
- Management of use of urinary antimuscarinics and alpha blockers for benign prostatic hyperplasia in older adults at risk of falls: a clinical review.European geriatric medicine · 2023Review
- Real-World Evidence for Risk Factors of Bruises and Fractures from Falls in Patients with Overactive Bladder: A Medical Record Analysis.International journal of clinical practice · 2023Article
- Risk factors for falls among older adults in India: A systematic review and meta-analysis.Health science reports · 2022Article
- Mirabegron for overactive bladder in frail patients 80 years or over (HOKUTO study).BMC urology · 2022Observational
- Safety and Tolerability of Fesoterodine in Older Adult Patients with Overactive Bladder.Canadian geriatrics journal : CGJ · 2022Review
- Risk Factors Associated with Falls among Nursing Home Residents: A Case-Control Study.Portuguese journal of public health · 2022Article
- A non-interventional cross-sectional re-contact study investigating the relationship between overactive bladder and frailty in older adults in Japan.BMC geriatrics · 2022Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionUrinary symptoms are associated with an increased risk of falls, but few studies have focused on patients with overactive bladder (OAB). This study aimed to synthesize estimates of the risk of falls and fractures in patients with OAB.
methodsMedline, EMBASE, the Cumulative Index to Nursing and Allied Health Literature, and Scopus were systematically searched for observational studies that focused on patients with OAB. When available, data from a non-OAB comparison sample were included. Double independent review and data extraction were performed. Falls and fractures data were summarized by unadjusted and adjusted risks, and percent attributable risk (PAR) of falls and fractures associated with OAB.
resultsFifteen studies were included in the analyses. The proportion of patients with OAB experiencing at least one fall over a year ranged from 18.9% to 50.0%, and the proportion of patients with OAB experiencing recurrent or serious falls ranged from 10.2% to 56.0%. In studies that included a non-OAB comparison sample, a higher risk of falls was observed in patients with OAB compared to those without. A significantly increased (1.3- to 2.3-fold) adjusted OAB-associated risk of falls was reported, while unadjusted PARs for OAB associated falls ranged from 3.7% to 15.5%. Risk was higher among women and those 65 years of age or older. While analysis of fractures showed elevated point estimates, most studies were underpowered to detect a statistically significant difference between groups.
conclusionsEvidence from the published literature clearly demonstrates the importance of OAB and its symptoms as risk factors for falls and fractures.
fundingAstellas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.