Evidence map›Paper›PMID 30255347›Full record

ArticleJournal of medical systems2018

Extraction of Ejection Fraction from Echocardiography Notes for Constructing a Cohort of Patients having Heart Failure with reduced Ejection Fraction (HFrEF).

Kavishwar B Wagholikar, Christina M Fischer, Alyssa Goodson, Christopher D Herrick, Martin Rees, Eloy Toscano, Calum A MacRae, Benjamin M Scirica, Akshay S Desai, Shawn N Murphy

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical systems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  14. Artificial intelligence in cardiovascular imaging: state of the art and implications for the imaging cardiologist.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Kavishwar B WagholikarHarvard Medical School, Boston, MA, USA. waghsk@gmail.com.ORCID http://orcid.org/0000-0002-6219-861X
Christina M FischerMassachusetts General Hospital, Boston, MA, USA.
Alyssa GoodsonPartners Healthcare, Boston, MA, USA.
Christopher D HerrickPartners Healthcare, Boston, MA, USA.
Martin ReesPartners Healthcare, Boston, MA, USA.
Eloy ToscanoPartners Healthcare, Boston, MA, USA.
Calum A MacRaeHarvard Medical School, Boston, MA, USA.
Benjamin M SciricaHarvard Medical School, Boston, MA, USA.
Akshay S DesaiHarvard Medical School, Boston, MA, USA.
Shawn N MurphyHarvard Medical School, Boston, MA, USA.
Mass General Brigham · USBrigham and Women's Hospital · USHarvard University · USMassachusetts General Hospital · US

Funding

Developing i2b2 into a Health Innovation Platform for Clinical Decision Support in the Genomics EraR01HG009174 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI ARONSON, SAMUEL JEFFREY, MACRAE, CALUM A. · 2016 to 2019
$2.9M
A Framework to Enhance Decision Support by Invoking NLP: Methods and ApplicationsR00LM011575 · NLM · MASSACHUSETTS GENERAL HOSPITAL · PI WAGHOLIKAR, KAVISHWAR B. · 2016 to 2018
$749k
National Human Genome Research Institute (US) R01-HG009174NLM NIH HHS R00 LM011575U.S. National Library of Medicine (US) R00-LM011575
6 · The paper itself

Abstract

Left ventricular ejection fraction (LVEF) is an important prognostic indicator of cardiovascular outcomes. It is used clinically to determine the indication for several therapeutic interventions. LVEF is most commonly derived using in-line tools and some manual assessment by cardiologists from standardized echocardiographic views. LVEF is typically documented in free-text reports, and variation in LVEF documentation pose a challenge for the extraction and utilization of LVEF in computer-based clinical workflows. To address this problem, we developed a computerized algorithm to extract LVEF from echocardiography reports for the identification of patients having heart failure with reduced ejection fraction (HFrEF) for therapeutic intervention at a large healthcare system. We processed echocardiogram reports for 57,158 patients with coded diagnosis of Heart Failure that visited the healthcare system over a two-year period. Our algorithm identified a total of 3910 patients with reduced ejection fraction. Of the 46,634 echocardiography reports processed, 97% included a mention of LVEF. Of these reports, 85% contained numerical ejection fraction values, 9% contained ranges, and the remaining 6% contained qualitative descriptions. Overall, 18% of extracted numerical LVEFs were ≤ 40%. Furthermore, manual validation for a sample of 339 reports yielded an accuracy of 1.0. Our study demonstrates that a regular expression-based approach can accurately extract LVEF from echocardiograms, and is useful for delineating heart-failure patients with reduced ejection fraction.

Indexed as

EchocardiographyStroke VolumeVentricular Function, LeftAlgorithmsHeart FailureHumansPrognosisCardiologyEchocardiogramEjection fractionNatural language processingRegular expression

Identifiers

PMID30255347
PMCPMC6153777
OpenAlexW2894204771

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.