Evidence map›Paper›PMID 30255192›Full record

ArticleSkeletal radiology2019

Five-year development of lumbar disc degeneration-a prospective study.

Elina Iordanova Schistad, Siri Bjorland, Cecilie Røe, Johannes Gjerstad, Nils Vetti, Kjersti Myhre, Ansgar Espeland

Abstract read
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In one paragraph

Article in Skeletal radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Two trajectories of lumbar disc degeneration from adolescence to adulthood: a 23-year longitudinal MRI study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  2. Article
  3. MiR-206 improves intervertebral disk degeneration by targeting GJA1.Journal of orthopaedic surgery and research · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elina Iordanova SchistadDepartment of Physical Medicine and Rehabilitation, Oslo University Hospital HF, Ulleval, Postbox 4956, Nydalen, 0424, Oslo, Norway. uxioel@ous-hf.no.ORCID http://orcid.org/0000-0003-4239-3298
Siri BjorlandDepartment of Physical Medicine and Rehabilitation, Oslo University Hospital HF, Ulleval, Postbox 4956, Nydalen, 0424, Oslo, Norway.
Cecilie RøeDepartment of Physical Medicine and Rehabilitation, Oslo University Hospital HF, Ulleval, Postbox 4956, Nydalen, 0424, Oslo, Norway.
Johannes GjerstadNational Institute of Occupational Health, Oslo, Norway.
Nils VettiDepartment of Radiology, Haukeland University Hospital, Bergen, Norway.
Kjersti MyhreDepartment of Physical Medicine and Rehabilitation, Oslo University Hospital HF, Ulleval, Postbox 4956, Nydalen, 0424, Oslo, Norway.
Ansgar EspelandDepartment of Radiology, Haukeland University Hospital, Bergen, Norway.
Oslo University Hospital · NOHaukeland University Hospital · NONational Institute of Occupational Health · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the impact of demographic, clinical, and genetic factors as well as herniated discs on 5-year development of disc degeneration in the lumbar spine, and to investigate associations between changes in lumbar degenerative findings and pain. MATERIALS AND

methodsIn 144 patients with lumbar radicular pain or low back pain, we scored disc degeneration, herniated discs, and high-intensity zones in the posterior annulus fibrosus on lumbar magnetic resonance imaging (MRI) at baseline and 5-year follow-up. Genotyping (TaqMan assay) was performed for genes encoding vitamin D receptor (VDR), collagen XIα (COL11A), matrix metalloproteinase 1/9 (MMP1/MMP9), and interleukin 1α/1RN (IL-1α/IL-1RN). Associations were analyzed using multivariate linear regression adjusted for age, sex, smoking, body mass index, and baseline scores for degenerated discs and herniated discs (when analyzing impact of baseline factors) or for pain (when analyzing associations with pain).

resultsProgression of disc degeneration over 5 years was significantly (p < 0.001) related to higher age and less disc degeneration at baseline, but not to sex, smoking, body mass index, herniated discs, or variants in the studied genes. No associations were identified between changes in disc degeneration or high-intensity zones and pain at 5-year follow-up. However, increased number of herniated discs over 5 years was associated with pain at rest (p = 0.019).

conclusionsAge and disc degeneration at baseline, rather than genetic factors, influenced the 5-year development of disc degeneration in patients with lumbar radicular pain or low back pain. Development of herniated discs was related to pain at rest.

Indexed as

Magnetic Resonance ImagingAdultAge FactorsCollagen Type XIDisease ProgressionFemaleGenotypeHumansInterleukin-1Intervertebral Disc DegenerationMaleMatrix Metalloproteinase 1Matrix Metalloproteinase 9Middle AgedPain MeasurementProspective StudiesCOL11A1 protein, humanCollagen Type XIInterleukin-1Matrix Metalloproteinase 1Matrix Metalloproteinase 9MMP1 protein, humanMMP9 protein, humanReceptors, CalcitriolCandidate gene polymorphismsDisc degenerationHerniated discHigh-intensity zoneLumbar spineMagnetic resonance imaging

Identifiers

PMID30255192
OpenAlexW2892433829

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.