Evidence map›Paper›PMID 30255030›Full record

ArticleInternational journal of genomics2018

Changes in miRNA Gene Expression during Wound Repair in Differentiated Normal Human Bronchial Epithelium.

Beata Narożna, Wojciech Langwiński, Claire Jackson, Peter M Lackie, John W Holloway, Zuzanna Stachowiak, Monika Dmitrzak-Węglarz, Aleksandra Szczepankiewicz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Beata NarożnaLaboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0002-1172-6312
Wojciech LangwińskiLaboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.
Claire JacksonClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Peter M LackieClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
John W HollowayClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0001-9998-0464
Zuzanna StachowiakLaboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.
Monika Dmitrzak-WęglarzDepartment of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0002-0493-8325
Aleksandra SzczepankiewiczLaboratory of Molecular and Cell Biology, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0003-3379-9106
Poznan University of Medical Sciences · PLUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAirway epithelium acts as a protective barrier against the particles from the inhaled air. Damage to the epithelium may result in loss of the barrier function. Epithelial repair in response to injury requires complex mechanisms, such as microRNA, small noncoding molecules, to regulate the processes involved in wound repair. We aimed to establish if the microRNA gene expression profile is altered during the airway epithelial repair in differentiated cells.

methodsmiRNA gene expression profile during the wound closure of differentiated normal human bronchial epithelium (NHBE) from one donor was analysed using quantitative real-time PCR. We have analysed the expression of 754 genes at five time points during a 48-hour period of epithelium repair using TaqMan Low Density Array.

resultsWe found out that 233 miRNA genes were expressed in normal human bronchial epithelium. Twenty miRNAs were differentially expressed during the wound repair process, but only one (miR-455-3p) showed significance after FDR adjustment (

conclusionsmiRNA expression profile is altered during airway epithelial repair of differentiated cells from one donor in response to mechanical injury

Identifiers

PMID30255030
PMCPMC6145058
OpenAlexW2891695767

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.