Evidence map›Paper›PMID 30254849›Full record

ArticleKidney research and clinical practice2018

Anti-phospholipase A2 receptor antibody as a prognostic marker in patients with primary membranous nephropathy.

Eun Joo Song, Kye Hwa Jeong, Young Ae Yang, Jeong-Hoon Lim, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park

Erratum issuedOpen access · diamondAbstract read
In one paragraph

Article in Kidney research and clinical practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. PLA2R autoantibodies, a multifaceted biomarker in nephrotic syndrome and membranous nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
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  9. The Role of Anti-PLAInternational journal of environmental research and public health · 2022
    Review
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  13. Advances in Pathogenesis of Idiopathic Membranous Nephropathy.Kidney diseases (Basel, Switzerland) · 2020
    Review
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  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Eun Joo SongDepartment of Internal Medicine, Daehyun Chumdan Geriatric Hospital, Daegu, Korea.
Kye Hwa JeongDivision of Nephrology and Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Young Ae YangDivision of Nephrology and Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Jeong-Hoon LimDivision of Nephrology and Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Hee-Yeon JungDivision of Nephrology and Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Ji-Young ChoiDivision of Nephrology and Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Jang-Hee ChoDivision of Nephrology and Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Chan-Duck KimDivision of Nephrology and Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Yong-Lim KimDivision of Nephrology and Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Sun-Hee ParkDivision of Nephrology and Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Kyungpook National University · KRHyoja Geriatric Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhospholipase A2 receptor (PLA2R) has been identified as a major autoantigen in primary membranous nephropathy (MN). We evaluated the association between anti-PLA2R antibodies and clinical outcome in Korean patients with primary MN.

methodsA total of 66 patients with biopsy-proven MN were included. Serum level of anti-PLA2R antibodies was measured by enzyme-linked immunosorbent assay. Biochemical parameters were estimated initially and at follow-up.

resultsAnti-PLA2R antibodies were detected in 52.1% and 27.8% of patients with primary and secondary MN, respectively. Forty-eight patients with primary MN were grouped based on presence or absence of anti-PLA2R antibodies. Proteinuria was more severe in anti-PLA2R-positive patients than in anti-PLA2R-negative patients (urine protein/creatinine ratio 7.922 ± 3.985 g/g vs. 4.318 ± 3.304 g/g,

conclusionDetection of anti-PLA2R antibodies at diagnosis in patients with primary MN can predict prognosis and guide treatment decisions.

Indexed as

Membranous nephropathyPhospholipase A2 receptorsPrognosis

Identifiers

PMID30254849
PMCPMC6147192
OpenAlexW2889948708

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.