Evidence map›Paper›PMID 30254828›Full record

ArticlePlastic and reconstructive surgery. Global open2018

Squid Ring Teeth-coated Mesh Improves Abdominal Wall Repair.

Ashley N Leberfinger, Monika Hospodiuk, Abdon Pena-Francesch, Bugra Ayan, Veli Ozbolat, Srinivas V Koduru, Ibrahim T Ozbolat, Melik C Demirel, Dino J Ravnic

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Polymer nanomaterials for use as adjuvant surgical tools.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ashley N LeberfingerDepartment of Surgery, Penn State University College of Medicine, Hershey, Pa.
Monika HospodiukDepartment of Engineering Science and Mechanics, Penn State University, University Park, Pa.
Abdon Pena-FranceschDepartment of Biomedical Engineering, Penn State University, University Park, Pa.
Bugra AyanDepartment of Engineering Science and Mechanics, Penn State University, University Park, Pa.
Veli OzbolatDepartment of Engineering Science and Mechanics, Penn State University, University Park, Pa.
Srinivas V KoduruDepartment of Surgery, Penn State University College of Medicine, Hershey, Pa.
Ibrahim T OzbolatDepartment of Engineering Science and Mechanics, Penn State University, University Park, Pa.
Melik C DemirelDepartment of Engineering Science and Mechanics, Penn State University, University Park, Pa.
Dino J RavnicDepartment of Surgery, Penn State University College of Medicine, Hershey, Pa.
Pennsylvania State University · USPenn State Milton S. Hershey Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHernia repair is a common surgical procedure with polypropylene (PP) mesh being the standard material for correction because of its durability. However, complications such as seroma and pain are common, and repair failures still approach 15% secondary to poor tissue integration. In an effort to enhance mesh integration, we evaluated the applicability of a squid ring teeth (SRT) protein coating for soft-tissue repair in an abdominal wall defect model. SRT is a biologically derived high-strength protein with strong mechanical properties. We assessed tissue integration, strength, and biocompatibility of a SRT-coated PP mesh in a first-time pilot animal study.

methodsPP mesh was coated with SRT (SRT-PP) and tested for mechanical strength against uncoated PP mesh. Cell proliferation and adhesion studies were performed in vitro using a 3T3 cell line. Rats underwent either PP (n = 3) or SRT-PP (n = 6) bridge mesh implantation in an anterior abdominal wall defect model. Repair was assessed clinically and radiographically, with integration evaluated by histology and mechanical testing at 60 days.

resultsCell proliferation was enhanced on SRT-PP mesh. This was corroborated in vivo by abdominal wall histology, dramatically diminished craniocaudal mesh contraction, improved strength testing, and higher tissue failure strain. There was no increase in seroma or visceral adhesion formation. No foreign body reactions were noted on liver histology.

conclusionsSRT applied as a coating appears to augment mesh-tissue integration and improve abdominal wall stability following bridged repair. Further studies in larger animals will determine its applicability for hernia repair in patients.

Identifiers

PMID30254828
PMCPMC6143318
OpenAlexW2951348486

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.