ArticleFrontiers in behavioral neuroscience2018
Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood.
Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Enduring effects of early-life adversity on reward processes: A systematic review and meta-analysis of animal studies.Neuroscience and biobehavioral reviews · 2022Pooled it
- Early-life adversity in rodents: Experimental design is of the essence.Neurobiology of stress · 2026Article
- Sensory Deprivation and the Brain: Neurobiological Mechanisms, Psychological Effects, and Clinical Implications.Brain sciences · 2026Review
- Evaluation of the Effects of Enlarged Housing on Social Play and Reward Seeking in Rats.Animals : an open access journal from MDPI · 2025Article
- Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia.Psychopharmacology · 2025Article
- Cerebrolysin Induces Dendritic Tree Plastic Changes and BDNF Increase in the Amygdala of Male Rats with Maternal Deprivation.Neurochemical research · 2025Article
- Maternal exposure to buprenorphine, but not methadone, during pregnancy reduces social play behavior across two generations of offspring.Psychopharmacology · 2025Article
- Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.Frontiers in neuroendocrinology · 2025Review
- Comparing the effects of infant maternal and sibling separation on adolescent behavior in rats (Rattus norvegicus).PloS one · 2024Article
- Behavioral effects of environmental enrichment on male and female wistar rats with early life stress experiences.Frontiers in physiology · 2022Article
- Altered social recognition memory and hypothalamic neuropeptide expression in adolescent male and female rats following prenatal alcohol exposure and/or early-life adversity.Psychoneuroendocrinology · 2021Article
- Maternal Separation Modifies the Activity of Social Processing Brain Nuclei Upon Social Novelty Exposure.Frontiers in behavioral neuroscience · 2021Article
- Complex Housing, but Not Maternal Deprivation Affects Motivation to Liberate a Trapped Cage-Mate in an Operant Rat Task.Frontiers in behavioral neuroscience · 2021Article
- Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on?Translational psychiatry · 2020Review
- The relevance of a rodent cohort in the Consortium on Individual Development.Developmental cognitive neuroscience · 2020Article
- Pro-social preference in an automated operant two-choice reward task under different housing conditions: Exploratory studies on pro-social decision making.Developmental cognitive neuroscience · 2020Article
- Childhood stress impairs social function through AVP-dependent mechanisms.Translational psychiatry · 2019Article
- Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early life context and stressful experiences are known to increase the risk of developing psychiatric disorders later in life, including disorders with deficits in the social domain. Our study aimed to investigate the influence of early life environment on social behavior in a well-controlled animal model. To this end we tested the effects of maternal deprivation (MD) on rat social play behavior in adolescence and social interaction in adulthood. Additionally, we provided a stimulating environment during adolescence (complex housing) as a potential intervention to diminish the effects of early life stress. Male and female Wistar rats were deprived from their mother for 24 h on postnatal day 3 (PND 3) or were left undisturbed. Complex housing started 5 days after weaning and consisted of housing 10 same-sex conspecifics in large, two-floor Marlau
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.