Evidence map›Paper›PMID 30254570›Full record

ArticleFrontiers in cellular neuroscience2018

Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine.

Yang Fan, Zhilu Chen, Janak L Pathak, Ana M D Carneiro, Chang Y Chung

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 65 citations in OpenAlex.

  1. [Mechanisms of Piezo1-mediated microglial ferroptosis in inhibiting spinal cord injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
  2. Article
  3. Article
  4. Identifying brain-penetrant small-molecule modulators of human microglia using a cellular model of synaptic pruning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  5. Article
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  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Dopamine, Immunity, and Disease.Pharmacological reviews · 2023
    Review
  15. Article
  16. Frontiers in psychiatry · 2023
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yang FanSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
Zhilu ChenSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
Janak L PathakSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
Ana M D CarneiroDepartment of Pharmacology, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, United States.
Chang Y ChungSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
Vanderbilt University Medical Center · US

Funding

Spatial Regulation of Cytoskeleton During ChemotaxisR01GM068097 · NIGMS · VANDERBILT UNIVERSITY · PI CHUNG, CHANG Y · 2003 to 2012
$2.7M
NIGMS NIH HHS R01 GM068097
6 · The paper itself

Abstract

Microglia, the immune competent cells of the central nervous system (CNS), normally exist in a resting state characterized by a ramified morphology with many processes, and become activated to amoeboid morphology in response to brain injury, infection, and a variety of neuroinflammatory stimuli. Many studies focused on how neurotransmitters affect microglia activation in pathophysiological circumstances. In this study, we tried to gain mechanistic insights on how dopamine (DA) released from neurons modulates cellular functions of resting and activated microglia. DA induced the reduction of the number of cellular processes, the increase of cell adhesion/spreading, and the increase of vimentin filaments in resting primary and BV

Indexed as

dopaminemicrogliap38MAPKpaxillinphagocytosis

Identifiers

PMID30254570
PMCPMC6141656
OpenAlexW2891455949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.