ArticleFrontiers in cellular neuroscience2018
Sleep and Wake Affect Glycogen Content and Turnover at Perisynaptic Astrocytic Processes.
Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Neurobiology of mitochondrial dynamics in sleep.The Journal of physiology · 2025Review
- Brain Glycogen-Its Metabolic Role in Neuronal Health and Neurological Disorders-An Extensive Narrative Review.Metabolites · 2025Review
- Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes.Cells · 2024Review
- Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture.Nature communications · 2024Article
- Circadian Mechanisms in Brain Fluid Biology.Circulation research · 2024Review
- How did I come to sleep research and stay there?Sleep advances : a journal of the Sleep Research Society · 2024Article
- Exploring Astrocyte-Mediated Mechanisms in Sleep Disorders and Comorbidity.Biomedicines · 2023Review
- The stress of losing sleep: Sex-specific neurobiological outcomes.Neurobiology of stress · 2023Article
- Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?Frontiers in cellular neuroscience · 2023Review
- Potential new roles for glycogen in epilepsy.Epilepsia · 2023Review
- FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function.Frontiers in systems neuroscience · 2023Article
- Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum.eLife · 2022Article
- The role of astrocyte structural plasticity in regulating neural circuit function and behavior.Glia · 2022Review
- The why and how of sleep-dependent synaptic down-selection.Seminars in cell & developmental biology · 2022Article
- Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways.eLife · 2021Article
- The Glial Perspective on Sleep and Circadian Rhythms.Annual review of neuroscience · 2020Review
- Effects of sleep and waking on the synaptic ultrastructure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Triheptanoin alters [U-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Neuromodulation of Glial Function During Neurodegeneration.Frontiers in cellular neuroscience · 2020Article
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Authors and funding
5 authors.
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Abstract
Astrocytic glycogen represents the only form of glucose storage in the brain, and one of the outcomes of its breakdown is the production of lactate that can be used by neurons as an alternative energetic substrate. Since brain metabolism is higher in wake than in sleep, it was hypothesized that glycogen stores are depleted during wake and replenished during sleep. Furthermore, it was proposed that glycogen depletion leads to the progressive increase in adenosine levels during wake, providing a homeostatic signal that reflects the buildup of sleep pressure. However, previous studies that measured glycogen dynamics across the sleep/wake cycle obtained inconsistent results, and only measured glycogen in whole tissue. Since most energy in the brain is used to sustain synaptic activity, here we employed tridimensional electron microscopy to quantify glycogen content in the astrocytic processes surrounding the synapse. We studied axon-spine synapses in the frontal cortex of young mice after ~7 h of sleep, 7-8 h of spontaneous or forced wake, or 4.5 days of sleep restriction. Relative to sleep, all wake conditions increased the number of glycogen granules around the synapses to a similar extent. However, progressively longer periods of wake were associated with progressively smaller glycogen granules, suggesting increased turnover. Despite the increased number of granules, in all wake conditions the estimated amount of glucose within the granules was lower than in sleep, indicating that sleep may favor glucose storage. Finally, chronic sleep restriction moved glycogen granules closer to the synaptic cleft. Thus, both short and long wake lead to increased glycogen turnover around cortical synapses, whereas sleep promotes glycogen accumulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.