Evidence map›Paper›PMID 30254407›Full record

ArticleWorld journal of gastroenterology2018

Adiponectin affects the mechanical responses in strips from the mouse gastric fundus.

Eglantina Idrizaj, Rachele Garella, Giovanni Castellini, Hermine Mohr, Natalia S Pellegata, Fabio Francini, Valdo Ricca, Roberta Squecco, Maria Caterina Baccari

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  8. Review
  9. Nitric Oxide: From Gastric Motility to Gastric Dysmotility.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Eglantina IdrizajDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy.
Rachele GarellaDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy.
Giovanni CastelliniPsychiatry Unit, Department of Health Sciences, University of Florence, Florence 50134, Italy.
Hermine MohrInstitute for Diabetes and Cancer Helmholtz Zentrum München, Neuherberg 85764, Germany.
Natalia S PellegataInstitute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg 85764, Germany.
Fabio FranciniDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy.
Valdo RiccaPsychiatry Unit, Department of Health Sciences, University of Florence, Florence 50134, Italy.
Roberta SqueccoDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy.
Maria Caterina BaccariDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy. mcaterina.baccari@unifi.it.
University of Florence · ITHelmholtz Zentrum München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate whether the adipocytes derived hormone adiponectin (ADPN) affects the mechanical responses in strips from the mouse gastric fundus.

methodsFor functional experiments, gastric strips from the fundal region were cut in the direction of the longitudinal muscle layer and placed in organ baths containing Krebs-Henseleit solution. Mechanical responses were recorded

resultsIn the functional experiments, EFS (4-16 Hz) elicited tetrodotoxin (TTX)-sensitive contractile responses. Addition of ADPN to the bath medium caused a reduction in amplitude of the neurally-induced contractile responses (

conclusionThe results indicate for the first time that ADPN is able to influence the mechanical responses in strips from the mouse gastric fundus.

Indexed as

AdipocytesAdiponectinAdipose Tissue, WhiteAnimalsElectric StimulationFemaleGastric FundusMiceMice, Inbred C57BLMuscle ContractionMuscle RelaxationMuscle, SmoothReceptors, AdiponectinAdiponectinadiponectin receptor 1, mouseadiponectin receptor 2, mouseAdipoq protein, mouseReceptors, AdiponectinAdiponectinAdiponectin receptorsGastric motilityNitric oxideNon-adrenergic, non-cholinergic neurotransmission

Identifiers

PMID30254407
PMCPMC6148421
OpenAlexW2890486154

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.