ReviewWorld journal of gastroenterology2018
Pediatric hepatocellular carcinoma.
Review in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 148 citations in OpenAlex.
- Primary non-hepatoblastoma liver tumors in children-Defining the profile of a very rare subset of childhood tumors.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Non-hepatoblastoma pediatric liver tumors: Unravelling of a lesser-known entity.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- AI-Driven Predictive Models of Early Recurrence of HCC After Surgical Resection: A Systematic Review.Cancers · 2026Review
- A Real World Analysis of Imaging Compared to Biopsy for Diagnosis of Pediatric Liver Tumors.Pediatric gastroenterology, hepatology & nutrition · 2026Article
- Survival analysis of laparoscopic and laparotomy hepatectomy for pediatric liver neoplasm: a single-center retrospective cohort study.Frontiers in pediatrics · 2026Article
- MRI major and ancillary features of LI-RADS for diagnosis of pediatric malignant liver tumors.European radiology · 2025Article
- Insights into the GALAD score: A new optimal cut-off for hepatocellular carcinoma.World journal of gastroenterology · 2025Article
- A diagnostic model based on transcriptomic analysis reveals inflammation as a potential prognosis factor for hepatoblastoma with hepatocellular carcinoma features.Cellular oncology (Dordrecht, Netherlands) · 2025Article
- Article
- Radiological and clinical signatures to differentiate hepatocellular carcinoma from hepatoblastoma in children older than 5 years of age: a feasibility study.Pediatric radiology · 2025Article
- Timing and Indications for Liver Transplantation for Children with Chronic Liver Disease.Children (Basel, Switzerland) · 2025Review
- Update on Pediatric Hepatitis C Infection.Current gastroenterology reports · 2025Review
- Pediatric Hepatocellular Carcinoma: A Review of Predisposing Conditions, Molecular Mechanisms, and Clinical Considerations.International journal of molecular sciences · 2025Review
- Safety and clinical efficacy of immune checkpoint inhibitors in pediatric hepatocellular carcinoma: a case report and review of the literature.Frontiers in oncology · 2025Article
- Case Report: A neoantigen-targeting peptide vaccine combined with checkpoint inhibition induces tumor regression and long-term remission in a pediatric patient with metastatic hepatocellular carcinoma.Frontiers in immunology · 2025Article
- Diagnosis, treatment, management and monitoring of patients with tyrosinaemia type 1: Consensus group recommendations from the German-speaking countries.Journal of inherited metabolic disease · 2025Review
- Incidence and survival of pediatric and adult hepatocellular carcinoma, United States, 2001-2020.Cancer epidemiology · 2024Article
- Worldwide burden of liver cancer across childhood and adolescence, 2000-2021: a systematic analysis of the Global Burden of Disease Study 2021.EClinicalMedicine · 2024Article
- Evaluation of surgical strategies and long-term outcomes in pediatric hepatocellular carcinoma.Pediatric surgery international · 2024Article
- Incidence and survival of pediatric and adult hepatocellular carcinoma, United States, 2001-2020.medRxiv : the preprint server for health sciences · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pediatric hepatocellular carcinoma (HCC) is the second common malignant liver tumor in children after hepatoblastoma. It differs from the adult HCC in the etiological predisposition, biological behavior and lower frequency of cirrhosis. Perinatally acquired hepatitis-B virus, hepatorenal tyrosinemia, progressive familial intrahepatic cholestasis, glycogen storage disease, Alagille's syndrome and congenital portosystemic shunts are important predisposing factors. Majority of children (87%) are older than 5 years of age. Following mass immunization against hepatitis-B, there has been a drastic fall in the incidence of new cases of pediatric HCC in the Asia-Pacific region. Management is targeted on complete surgical removal either by resection or liver transplantation. There is a trend towards improving survival of children transplanted for HCC beyond Milan criteria. Chemotherapeutic regimens do not offer good results but may be helpful for down-staging of advanced HCC. Surveillance of children with chronic liver diseases with ultrasound and alpha-fetoprotein may be helpful in timely detection, intervention and overall improvement in outcome of HCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.