Evidence map›Paper›PMID 30254402›Full record

ArticleWorld journal of gastroenterology2018

Biomarkers for hepatocellular carcinoma: What's new on the horizon?

Matthias Ocker

Abstract readEditorial
In one paragraph

Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Establishing peripheral PD-L1 as a prognostic marker in hepatocellular carcinoma patients: how long will it come true?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021
    Pooled it
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  3. Evaluating the role of preoperative serum insulin-like growth factor 1 as a predictor of survival and recurrence for patients with resectable hepatocellular carcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2026
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  20. CancerLivER: a database of liver cancer gene expression resources and biomarkers.Database : the journal of biological databases and curation · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Matthias OckerDepartment of Translational Medicine Oncology, Bayer AG, Berlin 13353, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of advanced hepatocellular carcinoma remains unsatisfying and so far only prognostic biomarkers like α-fetoprotein have been established. No clear predictive biomarker is currently available for standard of care therapies, including targeted therapies like sorafenib. Novel therapeutic options like immune checkpoint inhibitors may pose new challenges to identification and validation of such markers. Currently, PD-L1 expression

Indexed as

Antineoplastic AgentsB7-H1 AntigenBiomarkers, TumorBiopsyCarcinoma, HepatocellularGlycomicsHigh-Throughput Nucleotide SequencingHumansLiverLiver NeoplasmsMolecular Targeted TherapyMutationPrognosisProteomicsTreatment OutcomeAntineoplastic AgentsB7-H1 AntigenBiomarkers, TumorCD274 protein, humanBiomarkerCirculating free DNACirculating tumor cellsFunctional imagingHepatocellular carcinomaImmune checkpoint inhibitorsLiquid BiopsyMolecular imagingNext-generation sequencing

Identifiers

PMID30254402
PMCPMC6148424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.