Evidence map›Paper›PMID 30254371›Full record

ArticleScientific reports2018

Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment.

Nandini Singarapu, Keyue Ma, Kaitlin A G Reeh, Jianjun Shen, Jessica N Lancaster, Song Yi, Huafeng Xie, Stuart H Orkin, Nancy R Manley, Lauren I R Ehrlich and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Thymus Ontogeny and Development.Advances in experimental medicine and biology · 2025
    Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Nandini SingarapuDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park, Smithville, Texas, 78957, USA.
Keyue MaDepartment of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Kaitlin A G ReehDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park, Smithville, Texas, 78957, USA.
Jianjun ShenDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park, Smithville, Texas, 78957, USA.
Jessica N LancasterDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID 0000-0003-0398-9988
Song YiDepartment of Oncology, Dell Medical School and Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Huafeng XieDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, 02115, USA.
Stuart H OrkinDivision of Hematology/Oncology, Boston Children's Hospital, Boston, MA, 02115, USA.
Nancy R ManleyDepartment of Genetics, Paul D. Coverdell Center, 500 DW Brooks Drive, University of Georgia, Athens, GA, 30602, USA.
Lauren I R EhrlichDepartment of Molecular Biosciences, Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, 78712, USA.ORCID 0000-0002-1697-1755
Ning JiangDepartment of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Ellen R RichieDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park, Smithville, Texas, 78957, USA. erichie@mdanderson.org.ORCID 0000-0003-0786-973X
The University of Texas MD Anderson Cancer Center · USThe University of Texas at Austin · USBoston Children's Hospital · USLivestrong Foundation · USUniversity of Georgia · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Thymic epithelial cells (TEC) are essential for thymocyte differentiation and repertoire selection. Despite their indispensable role in generating functional T cells, the molecular mechanisms that orchestrate TEC development from endodermal progenitors in the third pharyngeal pouch (3

Indexed as

AnimalsCell DifferentiationCell LineageEpithelial CellsGene DeletionGene Expression RegulationHistonesMethylationMicePolycomb Repressive Complex 2T-Box Domain ProteinsThymus GlandEed protein, mouseHistonesPolycomb Repressive Complex 2T-Box Domain ProteinsTbx1 protein, mouse

Identifiers

PMID30254371
PMCPMC6156232
OpenAlexW2892190591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.