ArticleInternational journal of obesity (2005)2019
Impact of obesity on angiogenic and inflammatory markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort.
Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Periconceptional biomarkers for maternal obesity: a systematic review.Reviews in endocrine & metabolic disorders · 2023Pooled it
- The association between sleep-disordered breathing and maternal endothelial and metabolic markers in pregnancies complicated by obesity.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Trial
- Observational
- Biomarkers predicting adverse pregnancy outcomes in women living with obesity: a systematic review and meta-analysis.AJOG global reports · 2025Review
- The Impact of Overweight and Obesity on Pregnancy: A Narrative Review of Physiological Consequences, Risks and Challenges in Prenatal Care, and Early Intervention Strategies.Current diabetes reports · 2025Review
- Significance of the sFlt-1/PlGF Ratio in Certain Cohorts - What Needs to be Considered?Geburtshilfe und Frauenheilkunde · 2024Article
- Literature Review: The sFlt1/PlGF Ratio and Pregestational Maternal Comorbidities: New Risk Factors to Predict Pre-Eclampsia.International journal of molecular sciences · 2023Review
- ABCB1 expression is increased in human first trimester placenta from pregnant women classified as overweight or obese.Scientific reports · 2023Article
- Performance of sFlt-1/PIGF Ratio for the Prediction of Perinatal Outcome in Obese Pre-Eclamptic Women.Journal of clinical medicine · 2022Article
- High early pregnancy body mass index is associated with alterations in first- and second-trimester angiogenic biomarkers.American journal of obstetrics & gynecology MFM · 2022Observational
- Antioxidants in Pregnancy: Do We Really Need More Trials?Antioxidants (Basel, Switzerland) · 2022Review
- Administration of recombinant human placental growth factor decreases blood pressure in obese hypertensive pregnant rats.Journal of hypertension · 2020Article
- High-fat diet from parental generation exaggerates body and adipose tissue weights in pregnant offspring.PloS one · 2020Article
- Obesity and Preeclampsia: Common Pathophysiological Mechanisms.Frontiers in physiology · 2018Review
- The Immunogenetic Conundrum of Preeclampsia.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile several studies have demonstrated that obesity increases the risk of pre-eclampsia (PE), the mechanisms have yet to be elucidated. We assessed the association between maternal/paternal obesity and PE and hypothesized that maternal body mass index (BMI) would be associated with an adverse inflammatory and angiogenic profile. High-sensitivity C-reactive protein (hs-CRP) and following serum angiogenic markers were determined: soluble endoglin (sEng), soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF).
methodsData on BMI were available from 1450 pregnant women with PE and 1065 without PE. Serum concentrations of hs-CRP and angiogenic markers were available from a subset at first and third trimesters.
resultsPrepregnancy BMI was higher in the PE group than in controls (mean ± SD) 25.3 ± 5.2 vs. 24.1 ± 4,4, p < 0.001, adjusted for parity, mother's age, and smoking status before pregnancy. Increased hs-CRP concentrations were observed in both PE and non-PE women similarly according to BMI category. In women with PE, a higher BMI was associated with lower sFlt-1 and sEng concentrations throughout the pregnancy (p = 0.004, p = 0.008, respectively). There were no differences in PlGF in PE women according to BMI.
conclusionsWe confirmed increased pre-pregnancy BMI in women with PE. Enhanced inflammatory state was confirmed in all women with overweight/obesity. Partly paradoxically we observed that PE women with obesity had less disturbed levels of angiogenic markers than normal weight women with PE. This should be taken into account when angiogenic markers are used in PE prediction.
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Registered trials
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