ArticleScientific reports2018
Unraveling connectivity changes due to dopaminergic therapy in chronically treated Parkinson's disease patients.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Priming cardiovascular exercise improves complex motor skill learning by affecting the trajectory of learning-related brain plasticity.Scientific reports · 2022Trial
- Resting-state motor network connectivity as a biomarker of Levodopa response in Parkinson's disease.Brain imaging and behavior · 2026Review
- Exploring gait automaticity and prefrontal brain activity during single and dual-task walking in aging and Parkinson's disease.Journal of neuroengineering and rehabilitation · 2026Article
- Dopamine alters functional gradients in Parkinson's disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neuroimaging and plasma evidence of early white matter loss in Parkinson's disease with poor outcomes.Brain communications · 2024Article
- Bradykinesia and rigidity modulated by functional connectivity between the primary motor cortex and globus pallidus in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease.Human brain mapping · 2023Article
- Altered Neurovascular Coupling for Multidisciplinary Intensive Rehabilitation in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuroimaging signatures predicting motor improvement to focused ultrasound subthalamotomy in Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Normalization effect of levodopa on hierarchical brain function in Parkinson's disease.Network neuroscience (Cambridge, Mass.) · 2022Article
- Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson's disease.Brain communications · 2022Article
- Structural MRI substrate of long-duration response to levodopa in Parkinson's disease: an exploratory study.Journal of neurology · 2021Article
- Functional Connectome in Parkinson's Disease and Parkinsonism.Current neurology and neuroscience reports · 2021Review
- Frequency-Specific Effects of Galvanic Vestibular Stimulation on Response-Time Performance in Parkinson's Disease.Frontiers in neurology · 2021Article
- Differential effects of deep brain stimulation and levodopa on brain activity in Parkinson's disease.Brain communications · 2020Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of dopaminergic therapy for Parkinson's disease (PD) on the brain functional architecture are still unclear. We investigated this topic in 31 PD patients (disease duration: 11.2 ± (SD) 3.6 years) who underwent clinical and MRI assessments under chronic dopaminergic treatment (duration: 8.3 ± (SD) 4.4 years) and after its withdrawal. Thirty healthy controls were also included. Functional and morphological changes were studied, respectively, with eigenvector centrality mapping and seed-based connectivity, and voxel-based morphometry. Patients off medication, compared to controls, showed increased connectivity in cortical sensorimotor areas extending to the cerebello-thalamo-cortical pathway and parietal and frontal brain structures. Dopaminergic therapy normalized this increased connectivity. Notably, patients showed decreased interconnectedness in the medicated compared to the unmedicated condition, encompassing putamen, precuneus, supplementary motor and sensorimotor areas bilaterally. Similarly, lower connectivity was found comparing medicated patients to controls, overlapping with the within-group comparison in the putamen. Seed-based analyses revealed that dopaminergic therapy reduced connectivity in motor and default mode networks. Lower connectivity in the putamen correlated with longer disease duration, medication dose, and motor symptom improvement. Notably, atrophy and connectivity changes were topographically dissociated. After chronic treatment, dopaminergic therapy decreases connectivity of key motor and default mode network structures that are abnormally elevated in PD off condition.
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