ArticleThe ISME journal2019
Microbiota and skin defense peptides may facilitate coexistence of two sympatric Andean frog species with a lethal pathogen.
Article in The ISME journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Host and Environmental Factors Outweigh Pathogen in Shaping Skin Microbiome of a Threatened Andean Amphibian Community.Molecular ecology · 2026Article
- Environmental factors associated with nesting habits and age shape the composition and connection between skin and uropygial gland microbiomes of birds.The Journal of animal ecology · 2026Article
- Changes to Skin Microbiome Community Dynamics Support Resistance to Enzootic and Epizootic Strains of Batrachochytrium dendrobatidis (Bd) in the Spotted Salamander (Ambystoma maculatum).Molecular ecology · 2026Article
- Novel antimicrobial peptides and peptide-microbiome crosstalk in Appalachian salamander skin.NPJ biofilms and microbiomes · 2025Article
- Exposure to Rice Straw Ash Alters Survival, Development and Microbial Diversity in Amphibian Tadpoles.Ecology and evolution · 2025Article
- The impact of microbiome diversity and composition on host health and susceptibility to disease across amphibian life stages.Frontiers in amphibian and reptile science · 2025Article
- Amphibian tolerance to arsenic: microbiome-mediated insights.Scientific reports · 2024Article
- Accelerating the Discovery and Design of Antimicrobial Peptides with Artificial Intelligence.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Host macrocyclic acylcarnitines mediate symbiotic interactions between frogs and their skin microbiome.iScience · 2023Article
- The adaptive microbiome hypothesis and immune interactions in amphibian mucus.Developmental and comparative immunology · 2023Review
- First Report of Culturable Skin Bacteria in Melanophryniscus admirabilis (Admirable Redbelly Toad).Microbial ecology · 2023Article
- Inhibitory Bacterial Diversity and Mucosome Function Differentiate Susceptibility of Appalachian Salamanders to Chytrid Fungal Infection.Applied and environmental microbiology · 2022Article
- Molecular basis of a bacterial-amphibian symbiosis revealed by comparative genomics, modeling, and functional testing.The ISME journal · 2022Article
- Spatiotemporal and ontogenetic variation, microbial selection, and predictedFrontiers in microbiology · 2022Article
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- Article
- Microbial Assemblage Dynamics Within the American Alligator Nesting Ecosystem: a Comparative Approach Across Ecological Scales.Microbial ecology · 2020Article
- Variation in the Slimy Salamander (Plethodon spp.) Skin and Gut-Microbial Assemblages Is Explained by Geographic Distance and Host Affinity.Microbial ecology · 2020Article
- Cathelicidin-DM is an Antimicrobial Peptide fromACS omega · 2020Article
- Antimicrobial peptide and sequence variation along a latitudinal gradient in two anurans.BMC genetics · 2020Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Management of hyper-virulent generalist pathogens is an emergent global challenge, yet for most disease systems we lack a basic understanding as to why some host species suffer mass mortalities, while others resist epizootics. We studied two sympatric species of frogs from the Colombian Andes, which coexist with the amphibian pathogen Batrachochytrium dendrobatidis (Bd), to understand why some species did not succumb to the infection. We found high Bd prevalence in juveniles for both species, yet infection intensities remained low. We also found that bacterial community composition and host defense peptides are specific to amphibian life stages. We detected abundant Bd-inhibitory skin bacteria across life stages and Bd-inhibitory defense peptides post-metamorphosis in both species. Bd-inhibitory bacteria were proportionally more abundant in adults of both species than in earlier developmental stages. We tested for activity of peptides against the skin microbiota and found that in general peptides did not negatively affect bacterial growth and in some instances facilitated growth. Our results suggest that symbiotic bacteria and antimicrobial peptides may be co-selected for, and that together they contribute to the ability of Andean amphibian species to coexist with the global pandemic lineage of Bd.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.