Evidence map›Paper›PMID 30254319›Full record

ArticleNature communications2018

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes.

Joern Pezoldt, Maria Pasztoi, Mangge Zou, Carolin Wiechers, Michael Beckstette, Guilhem R Thierry, Ehsan Vafadarnejad, Stefan Floess, Panagiota Arampatzi, Manuela Buettner and 14 more

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Fibroblast diversity within human gut-associated lymphoid tissues.The Journal of experimental medicine · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Transport functions of intestinal lymphatic vessels.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Protective fibroblastic niches in secondary lymphoid organs.The Journal of experimental medicine · 2024
    Review
  17. Lymph node stromal cell responses to perinatal T cell waves, a temporal atlas.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Identification of human exTNature immunology · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Joern PezoldtDepartment Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.ORCID http://orcid.org/0000-0001-7143-5691
Maria PasztoiDepartment Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Mangge ZouDepartment Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Carolin WiechersDepartment Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Michael BeckstetteDepartment Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Guilhem R ThierryCNRS, INSERM, CIML, Aix Marseille University, 13284, Marseille, France.
Ehsan VafadarnejadHelmholtz Institute for RNA-based Infection Research, 97080, Wuerzburg, Germany.
Stefan FloessDepartment Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Panagiota ArampatziCore Unit Systems Medicine, University of Wuerzburg, 97080, Wuerzburg, Germany.ORCID http://orcid.org/0000-0001-7925-8984
Manuela BuettnerInstitute of Functional and Applied Anatomy, Hannover Medical School, 30625, Hannover, Germany.
Janina SchweerDepartment Molecular Infection Biology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Diana FleissnerDepartment Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Marius VitalResearch Group Microbial Interactions and Processes, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Dietmar H PieperResearch Group Microbial Interactions and Processes, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Marijana BasicInstitute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, 30625, Hannover, Germany.
Petra DerschDepartment Molecular Infection Biology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.
Till StrowigResearch Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany.ORCID http://orcid.org/0000-0003-0185-1459
Mathias HornefInstitute of Medical Microbiology, RWTH Aachen, 52074, Aachen, Germany.
André BleichInstitute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0002-3438-0254
Ulrike BodeInstitute of Functional and Applied Anatomy, Hannover Medical School, 30625, Hannover, Germany.
Oliver PabstInstitute of Molecular Medicine, RWTH Aachen, 52074, Aachen, Germany.
Marc BajénoffCNRS, INSERM, CIML, Aix Marseille University, 13284, Marseille, France.
Antoine-Emmanuel SalibaHelmholtz Institute for RNA-based Infection Research, 97080, Wuerzburg, Germany.ORCID http://orcid.org/0000-0001-8539-2784
Jochen HuehnDepartment Experimental Immunology, Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany. Jochen.Huehn@helmholtz-hzi.de.ORCID http://orcid.org/0000-0001-8071-1379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut-draining mesenteric lymph nodes (mLNs) are important for inducing peripheral tolerance towards food and commensal antigens by providing an optimal microenvironment for de novo generation of Foxp3

Indexed as

AnimalsAnimals, NewbornCellular MicroenvironmentDendritic CellsForkhead Transcription FactorsGene Expression ProfilingImmune ToleranceLymph NodesMesenteryMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, TransgenicStromal CellsT-Lymphocytes, RegulatoryForkhead Transcription FactorsFoxp3 protein, mouse

Identifiers

PMID30254319
PMCPMC6156403

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.