ArticleNature communications2018
Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Pooled it
- Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden.Journal of the National Cancer Institute · 2022Pooled it
- Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.PLoS genetics · 2021Pooled it
- Independent and joint effects of lifestyle, human leukocyte antigen polymorphisms on cancer risk: findings from the UK Biobank.Frontiers in immunology · 2026Article
- Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Review
- Sarcoidosis in the Genomic Era: From Genetic Drivers to Tailored Therapies.Current allergy and asthma reports · 2025Review
- Article
- HLA gene polymorphism is a modifier of age-related breast cancer penetrance in carriers of BRCA1 pathogenic alleles.Breast cancer research and treatment · 2025Article
- Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes.Nature communications · 2024Article
- An immunogenetic basis for lung cancer risk.Science (New York, N.Y.) · 2024Article
- Context-aware single-cell multiome approach identified cell-type specific lung cancer susceptibility genes.bioRxiv : the preprint server for biology · 2023Article
- Lung Cancer Risk and Delivering on the Promise of the Genomic Era.American journal of respiratory and critical care medicine · 2023Article
- Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and commonFrontiers in immunology · 2023Article
- Distinct T helper cell-mediated antitumor immunity: T helper 2 cells in focus.Cancer pathogenesis and therapy · 2023Review
- Solving the puzzle of what makes immunotherapies work.Trends in cancer · 2022Review
- Functional studies of lung cancer GWAS beyond association.Human molecular genetics · 2022Review
- Prioritized candidate causal haplotype blocks in plant genome-wide association studies.PLoS genetics · 2022Article
- A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2022Article
- Overview of Research on Germline Genetic Variation in Immune Genes and Cancer Outcomes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- HLA imputation and its application to genetic and molecular fine-mapping of the MHC region in autoimmune diseases.Seminars in immunopathology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
73 authors at 20 institutions in 19 countries.
Aida Ferreiro-IglesiasInternational Agency for Research on Cancer, World Health Organization, Lyon, 69372 cedex 08, France.
Corina LesseurInternational Agency for Research on Cancer, World Health Organization, Lyon, 69372 cedex 08, France.
James McKayInternational Agency for Research on Cancer, World Health Organization, Lyon, 69372 cedex 08, France.
Rayjean J HungLunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto, Toronto, M5G 1X5, Canada.
Younghun HanBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.
Xuchen ZongLunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto, Toronto, M5G 1X5, Canada.
David ChristianiDepartment of Environmental Health, Harvard TH Chan School of Public Health, Massachusetts General Hospital/ Harvard Medical School, Boston, 02115, MA, USA.
Mattias JohanssonInternational Agency for Research on Cancer, World Health Organization, Lyon, 69372 cedex 08, France.
Xiangjun XiaoBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.
Yafang LiBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.
David C QianBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.
Xuemei JiBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.
Geoffrey LiuLunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto, Toronto, M5G 1X5, Canada.
Neil CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892-9768, MD, USA.
Ghislaine SceloInternational Agency for Research on Cancer, World Health Organization, Lyon, 69372 cedex 08, France.
David ZaridzeRussian N.N. Blokhin Cancer Research Centre, Moscow, 115478, Russian Federation.
Anush MukeriyaRussian N.N. Blokhin Cancer Research Centre, Moscow, 115478, Russian Federation.
Milica KonticClinical Center of Serbia, Belgrade, 11000, Serbia.
Simona OgnjanovicInternational Organization for Cancer Prevention and Research, Belgrade, 11070, Serbia.
Jolanta LissowskaM. Sklodowska-Curie Cancer Center, Institute of Oncology, Warsaw, 02-034, Poland.
Małgorzata SzołkowskaDepartment of Pathology, National Tuberculosis and Lung Diseases Research Institute, Warsaw, 01-138, Poland.
Beata SwiatkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, 91-348, Poland.
Vladimir JanoutFaculty of Medicine, University of Olomouc, Olomouc, 701 03, Czech Republic.
Ivana Holcatova2nd Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University, Prague, CZ 128 00, Czech Republic.
Ciprian BolcaInstitute of Pneumology "Marius Nasta", Bucharest, RO-050159, Romania.
Milan SavicDepartment of Thoracic Surgery Clinical Center of Serbia Belgrade, Belgrade, 11000, Serbia.
Miodrag OgnjanovicInternational Organization for Cancer Prevention and Research, Belgrade, 11070, Serbia.
Stig Egil BojesenCopenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen, 2730, Denmark.ORCID http://orcid.org/0000-0002-4061-4133
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.ORCID http://orcid.org/0000-0001-5174-3769
Demetrios AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892-9768, MD, USA.
Melinda C AldrichDepartment of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, 37232-4682, TA, USA.
Adonina TardonUniversity of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, 33006, Spain.
Ana Fernandez-SomoanoUniversity of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, 33006, Spain.ORCID http://orcid.org/0000-0002-8135-9079
Guillermo Fernandez-TardonUniversity of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, 33006, Spain.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, 96813, HI, USA.
Gadi RennertClalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, 3525433, Israel.ORCID http://orcid.org/0000-0002-8512-068X
Chu ChenDepartment of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, 98195, WA, USA.
Jennifer DohertyDepartment of Epidemiology, University of Washington School of Public Health and Community Medicine, Seattle, 98195, WA, USA.
Gary GoodmanSwedish Medical Group, Seattle, 98104, WA, USA.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, 37073, Germany.
H-Erich WichmannInstitute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig Maximilians University, Munich, D-85764, Germany.
Angela RischUniversity of Salzburg and Cancer Cluster Salzburg, Salzburg, 5020, Austria.ORCID http://orcid.org/0000-0002-8026-5505
Albert RosenbergerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, 37073, Germany.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Jiangsu Collaborative Innovation Center for Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Juncheng DaiDepartment of Epidemiology and Biostatistics, Jiangsu Collaborative Innovation Center for Cancer Medicine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
John K FieldInstitute of Translational Medicine, University of Liverpool, Liverpool, L3 9TA, UK.
Michael DaviesInstitute of Translational Medicine, University of Liverpool, Liverpool, L3 9TA, UK.
Penella WollDepartment of Oncology, University of Sheffield, Sheffield, S10 2RX, UK.
M Dawn TeareSchool of Health and Related Research, University Of Sheffield, England, S1 4DA, UK.
Lambertus A KiemeneyRadboud University Medical Center, Nijmegen, 9500, The Netherlands.
Erik H F M van der HeijdenRadboud University Medical Center, Nijmegen, 9500, The Netherlands.ORCID http://orcid.org/0000-0003-3596-518X
Jian-Min YuanUniversity of Pittsburgh Cancer Institute, Pittsburgh, 15232, PA, USA.
Yun-Chul HongDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, 110-799, Republic of Korea.
Aage HaugenNational Institute of Occupational Health, Oslo, N-0033, Norway.
Shanbeh ZienolddinyNational Institute of Occupational Health, Oslo, N-0033, Norway.
Stephen LamBritish Columbia Cancer Agency, Vancouver, V5Z 1M9, Canada.
Ming-Sound TsaoPrincess Margaret Cancer Centre, Toronto, ON M5G 1L7, Canada.
Mikael JohanssonDepartment of Radiation Sciences, Umeå University, Umeå, 901 85, Sweden.
Kjell GrankvistDepartment of Medical Biosciences, Umeå University, Umeå, 901 85, Sweden.ORCID http://orcid.org/0000-0003-4289-2097
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, 33612, FL, USA.ORCID http://orcid.org/0000-0003-3241-3216
Angeline AndrewBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.
Eric DuellUnit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, 08908, Spain.
Olle MelanderDepartment of Clinical Sciences Malmö, Lund University, Malmö, 221 00, Sweden.
Hans BrunnströmLaboratory Medicine Region Skåne, Department of Clinical Sciences Lund, Pathology, Lund University, Lund, 221 00, Sweden.
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, 99202, WA, USA.
Susanne ArnoldUniversity of Kentucky, Markey Cancer Center, Lexington, 40536-0098, KY, USA.ORCID http://orcid.org/0000-0001-6542-9551
Stacey SloneUniversity of Kentucky, Markey Cancer Center, Lexington, 40536-0098, KY, USA.
Jinyoung ByunBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.ORCID http://orcid.org/0000-0001-8579-1435
Ahsan KamalBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.
Dakai ZhuBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892-9768, MD, USA.
Christopher I AmosBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03755, NH, USA.ORCID http://orcid.org/0000-0002-8540-7023
Paul BrennanInternational Agency for Research on Cancer, World Health Organization, Lyon, 69372 cedex 08, France. BrennanP@iarc.fr.ORCID http://orcid.org/0000-0002-0518-8714
Dartmouth College · USCentre international de recherche sur le cancer · FRNational Institutes of Health · USUniversidad de Oviedo · ESUniversity of Toronto · CACentar za Promociju Nauke · RSNanjing Medical University · CNNational Institute of Occupational Health · NORadboud University Nijmegen · NLRussian Cancer Research Center NN Blokhin · RUUniversity of Göttingen · DEUniversity of Kentucky · USUniversity of Liverpool · GBUniversity of Sheffield · GBUniversity of Washington · USBC Cancer Agency · CACarmel Medical Center · ILCharles University · CZHarvard University · USHelmholtz Zentrum München · DE
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos · 2017 to 2026
$23.7MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MAlpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) StudyZIACP010195 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBANES, DEMETRIUS · 2009 to 2025
$22.5MTHE ROLE OF CAL IN CIF-MEDIATED DEGRADATION OF CFTRP20RR018787 · NCRR · DARTMOUTH COLLEGE · PI GERBER, SCOTT · 2003 to 2011
$21.9MVALIDATION OF A DIET HISTORY METHOD FOR EPIDEMIOLOGIC STUDIES OF CANCERP01CA033619 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 1985 to 2010
$18.5MValidation of Biomarkers of Risk for the Early Detection of Lung CancerU01CA152662 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DEPPEN, STEPHEN, GROGAN, ERIC L · 2010 to 2025
$12.8MTranslational studies of Hsp90 inhibitors in NSCLCP50CA090578 · NCI · DANA-FARBER CANCER INST · PI YEAP, BEOW Y · 2008 to 2012
$11.4MUnderstanding Ethnic Differences in Cancer: The Multiethnic Cohort StudyUM1CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HENDERSON, BRIAN E, LE MARCHAND, LOIC · 2012 to 2014
$11.3MNCATS NIH HHS UL1 TR000445NCI NIH HHS K07 CA172294NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA068384NCI NIH HHS P20 CA090578NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA090578NCI NIH HHS P50 CA119997NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA111703NCI NIH HHS R01 CA144034NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA152662NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA186145NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA203654NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA167462NCI NIH HHS UM1 CA182876NCRR NIH HHS P20 RR018787NCRR NIH HHS S10 RR025141NHGRI NIH HHS U01 HG004798NIDCR NIH HHS R01 DE013158NIEHS NIH HHS R01 ES025460World Health Organization 001
Abstract
Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.
Indexed as
Chromosome MappingAsian PeopleFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHLA AntigensHumansLung NeoplasmsMajor Histocompatibility ComplexMaleMiddle AgedPeptidesPolymorphism, Single NucleotideWhite PeopleHLA AntigensPeptides
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