Evidence map›Paper›PMID 30254253›Full record

ArticleScientific reports2018

En Face and Cross-sectional Corneal Tomograms Using Sub-micron spatial resolution Optical Coherence Tomography.

Yu-Tung Chen, Chia-Ying Tsai, Yu-Kuang Chiu, Ting-Wei Hsu, Lily Wei Chen, Wei-Li Chen, Sheng-Lung Huang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  5. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yu-Tung ChenGraduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan.
Chia-Ying TsaiDepartment of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Yu-Kuang ChiuGraduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan.
Ting-Wei HsuGraduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan.
Lily Wei ChenDepartment of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
Wei-Li ChenDepartment of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. chenweili@ntu.edu.tw.ORCID 0000-0002-1418-4221
Sheng-Lung HuangGraduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei, Taiwan. shuang@ntu.edu.tw.ORCID 0000-0001-6244-1555
National Taiwan University · TWFu Jen Catholic University · TWNational Taiwan University Hospital · TW

Funding

Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 106-2627-M-002-020Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 106-2627-M-002-032
6 · The paper itself

Abstract

Accurate diagnosis of corneal pathology and morphological identification of different corneal layers require clear delineation of corneal three-dimensional structures and en face or cross-sectional imaging of palisade of Vogt (POV), neovascularization (NV) or corneal nerves. Here we report a prototype of full-field optical coherence tomography (FF-OCT) system with isotropic sub-micron spatial resolution in the en face and cross-sectional views. It can also provide three-dimensional reconstructed images and a large field of view (FOV) by stitching tomograms side by side. We validated the imaging power of this prototype in in vivo rat and rabbit eyes, and quantified anatomical characteristics such as corneal layer thickness, endothelial cell density and the intensity profile of different layers. This FF-OCT delineated the ridge-like structure of POV, corneal nerve bundles, and conjunctival vessels in rat eyes. It also clearly identified the vessel walls and red blood cells in rabbit model of corneal NV. The findings provided by this FF-OCT are expected to facilitate corneal disease diagnosis and treatment.

Indexed as

Tomography, Optical CoherenceAnimalsCorneaMaleRabbitsRatsRegional Blood FlowSignal-To-Noise Ratio

Identifiers

PMID30254253
PMCPMC6156507
OpenAlexW2892064071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.