Evidence map›Paper›PMID 30254252›Full record

ArticleScientific reports2018

Age-Structured Population Modeling of HPV-related Cervical Cancer in Texas and US.

Ho-Lan Peng, Samantha Tam, Li Xu, Kristina R Dahlstrom, Chi-Fang Wu, Shuangshuang Fu, Chengxue Zhong, Wenyaw Chan, Erich M Sturgis, Lois Ramondetta and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. What cancers explain the growing rural-urban gap in human papillomavirus-associated cancer incidence?The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ho-Lan PengDepartment of Management, Policy and Community Health, School of Public Health, The University of Texas Health Science Center at Houston, 1200, Pressler Street, Houston, TX, USA.
Samantha TamDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, 1515, Holcombe Blvd, Houston, TX, USA.
Li XuDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, 1515, Holcombe Blvd, Houston, TX, USA.
Kristina R DahlstromDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, 1515, Holcombe Blvd, Houston, TX, USA.ORCID 0000-0002-8116-9558
Chi-Fang WuDepartment of Management, Policy and Community Health, School of Public Health, The University of Texas Health Science Center at Houston, 1200, Pressler Street, Houston, TX, USA.
Shuangshuang FuDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, 1200, Pressler Street, Houston, TX, USA.
Chengxue ZhongDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, 1200, Pressler Street, Houston, TX, USA.
Wenyaw ChanDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, 1200, Pressler Street, Houston, TX, USA.
Erich M SturgisDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, 1515, Holcombe Blvd, Houston, TX, USA.
Lois RamondettaDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1515, Holcombe Blvd, Houston, TX, USA.
Libin RongDepartment of Mathematics, University of Florida, 1400, Stadium Rd, Gainesville, FL, USA.
David R LairsonDepartment of Management, Policy and Community Health, School of Public Health, The University of Texas Health Science Center at Houston, 1200, Pressler Street, Houston, TX, USA.
Hongyu MiaoDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, 1200, Pressler Street, Houston, TX, USA. Hongyu.Miao@uth.tmc.edu.ORCID 0000-0002-4131-3164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papillomavirus (HPV)-related cervical cancer is a major public health threat to women, with >10,000 new cases diagnosed annually in the United States between 2008 and 2012. Since HPV vaccines can protect against ~80% of HPV-associated cervical cancers, the economic and epidemiological impacts of HPV vaccination have been extensively investigated, particularly at the national level. However, vaccination policies are state-specific, and state-level models are required for state-specific policy decisions. This study adapted an age-structured population model to describe the dynamics of HPV-related cervical cancer in Texas, with model parameters calibrated for Texas. The Year 2000 parameter set was the start point, and the model's predictions from 2001-2010 were well matched with the real incidence numbers in 23 age groups, suggesting the validity of the model. Application of the model to the Year 2010 parameter set predicted that, over the next 10 decades, incidence would decrease rapidly within the first decade and more slowly thereafter. Sensitivity analysis determined the impact of selected parameters (e.g., vaccine coverage rate) on future disease incidence. When compared with the US parameter sets, the Texas population was more sensitive to changes in HPV transmission and vaccination (e.g., ~8% difference in the predicted disease decline).

Indexed as

Models, StatisticalAdultAgedAged, 80 and overAge DistributionFemaleHumansMiddle AgedPapillomaviridaeSexual BehaviorTexasUterine Cervical NeoplasmsVaccinationYoung Adult

Identifiers

PMID30254252
PMCPMC6156590

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.