Evidence map›Paper›PMID 30254248›Full record

ArticleNature communications2018

RNA editing derived epitopes function as cancer antigens to elicit immune responses.

Minying Zhang, Jens Fritsche, Jason Roszik, Leila J Williams, Xinxin Peng, Yulun Chiu, Chih-Chiang Tsou, Franziska Hoffgaard, Valentina Goldfinger, Oliver Schoor and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 153 citations in OpenAlex.

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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 6 institutions in 4 countries.

Minying ZhangDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 904, Houston, TX, 77054, USA.
Jens FritscheImmatics Biotechnologies, Paul-Ehrlich-Str 15, 72076, Tübingen, Germany.ORCID http://orcid.org/0000-0002-5557-8577
Jason RoszikDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 904, Houston, TX, 77054, USA.ORCID http://orcid.org/0000-0002-4561-6170
Leila J WilliamsDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 904, Houston, TX, 77054, USA.ORCID http://orcid.org/0000-0002-9833-859X
Xinxin PengDepartment of Bioinformatics and Computation Biology, The University of Texas MD Anderson Cancer Center, P. O. Box 301402, Houston, TX, 77230, USA.
Yulun ChiuDepartment of Bioinformatics and Computation Biology, The University of Texas MD Anderson Cancer Center, P. O. Box 301402, Houston, TX, 77230, USA.
Chih-Chiang TsouImmatics US, 2130W Holcombe Blvd, Houston, TX, 77030, USA.
Franziska HoffgaardImmatics Biotechnologies, Paul-Ehrlich-Str 15, 72076, Tübingen, Germany.
Valentina GoldfingerImmatics Biotechnologies, Paul-Ehrlich-Str 15, 72076, Tübingen, Germany.
Oliver SchoorImmatics Biotechnologies, Paul-Ehrlich-Str 15, 72076, Tübingen, Germany.
Amjad TalukderDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 904, Houston, TX, 77054, USA.
Marie A ForgetDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 904, Houston, TX, 77054, USA.
Cara HaymakerDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 904, Houston, TX, 77054, USA.
Chantale BernatchezDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 904, Houston, TX, 77054, USA.
Leng HanDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, 6431 Fannin Street MSB 6.200, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-7380-2640
Yiu-Huen TsangDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, Houston, TX, 77030, USA.
Kathleen KongDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, Houston, TX, 77030, USA.
Xiaoyan XuDepartment of Bioinformatics and Computation Biology, The University of Texas MD Anderson Cancer Center, P. O. Box 301402, Houston, TX, 77230, USA.
Kenneth L ScottDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, BCM225, Houston, TX, 77030, USA.
Harpreet Singh-JasujaImmatics Biotechnologies, Paul-Ehrlich-Str 15, 72076, Tübingen, Germany.
Greg LizeeDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 904, Houston, TX, 77054, USA.
Han LiangDepartment of Bioinformatics and Computation Biology, The University of Texas MD Anderson Cancer Center, P. O. Box 301402, Houston, TX, 77230, USA.ORCID http://orcid.org/0000-0001-7633-286X
Toni WeinschenkImmatics Biotechnologies, Paul-Ehrlich-Str 15, 72076, Tübingen, Germany. weinschenk@immatics.com.ORCID http://orcid.org/0000-0001-8644-0290
Gordon B MillsDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77230, USA. gmills@mdanderson.org.
Patrick HwuDepartment of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, Unit 904, Houston, TX, 77054, USA. phwu@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USImmatics Biotechnologies (Germany) · DEBaylor College of Medicine · USImec the Netherlands · NLShenyang Medical College · CNThe University of Texas Health Science Center at Houston · US

Funding

TCPA: an Integrated Bioinformatics Resource for Functional Cancer Proteomic DataU24CA209851 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIANG, HAN, MILLS, GORDON B. · 2016 to 2020
$4.0M
Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancerU01CA217842 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DENEEN, BENJAMIN, MILLS, GORDON B. · 2017 to 2021
$3.6M
Systematic Functional Characterization of RNA Editing in Endometrial CancerR01CA175486 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIANG, HAN · 2014 to 2018
$1.7M
NCI NIH HHS R01 CA175486NCI NIH HHS U01 CA217842NCI NIH HHS U24 CA209851
6 · The paper itself

Abstract

In addition to genomic mutations, RNA editing is another major mechanism creating sequence variations in proteins by introducing nucleotide changes in mRNA sequences. Deregulated RNA editing contributes to different types of human diseases, including cancers. Here we report that peptides generated as a consequence of RNA editing are indeed naturally presented by human leukocyte antigen (HLA) molecules. We provide evidence that effector CD8

Indexed as

Antigen PresentationAntigens, NeoplasmCD8-Positive T-LymphocytesCell Line, TumorCells, CulturedCyclin ICytotoxicity, ImmunologicEpitopesHLA AntigensHumansImmune SystemNeoplasmsPeptidesProteogenomicsRNA EditingAntigens, NeoplasmCyclin IEpitopesHLA AntigensPeptides

Identifiers

PMID30254248
PMCPMC6156571
OpenAlexW2891169704

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.