ArticlePediatric research2019
The long-term effect of perinatal asphyxia on hippocampal volumes.
Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Volumetric differences in the brain in children with hypoxic-ischemic encephalopathy after therapeutic hypothermia: a review of MRI findings.Polish journal of radiology · 2026Review
- Does Antenatal Lactoferrin Protect Hippocampal Development in Ovine Fetuses with Growth Restriction?Cells · 2025Article
- Functional brain connectivity in early adolescence after hypothermia-treated neonatal hypoxic-ischemic encephalopathy.Pediatric research · 2025Article
- Neuroprotective Effect of Salvianolic Acid C in Neonatal Rats Following Hypoxic-ischemic Brain Damage.Molecular neurobiology · 2025Article
- Enhancing daily life for children with cognitive developmental delay through insights into brain development.Pediatric research · 2024Review
- Oxytocin Exhibits Neuroprotective Effects on Hippocampal Cultures under Severe Oxygen-Glucose Deprivation Conditions.Current issues in molecular biology · 2024Article
- Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies.Pediatric research · 2024Review
- Clinical-functional correlation with brain volumetry in severe perinatal asphyxia: a case report.Italian journal of pediatrics · 2024Article
- Advancing brain MRI as a prognostic indicator in hypoxic-ischemic encephalopathy.Pediatric research · 2024Article
- TrkB-mediated sustained neuroprotection is sex-specific and Erα-dependent in adult mice following neonatal hypoxia ischemia.Biology of sex differences · 2024Article
- Subcortical brain volumes in neonatal hypoxic-ischemic encephalopathy.Pediatric research · 2023Article
- Reduced Hippocampal Volumes in Children with History of Hypoxic Ischemic Encephalopathy after Therapeutic Hypothermia.Children (Basel, Switzerland) · 2023Article
- Mammillary body abnormalities and cognitive outcomes in children cooled for neonatal encephalopathy.Developmental medicine and child neurology · 2023Article
- Brain volumes and functional outcomes in children without cerebral palsy after therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy.Developmental medicine and child neurology · 2023Article
- Of differing methods, disputed estimates and discordant interpretations: the meta-analytical multiverse of brain volume and IQ associations.Royal Society open science · 2022Article
- Magnetic Resonance Imaging in (Near-)Term Infants with Hypoxic-Ischemic Encephalopathy.Diagnostics (Basel, Switzerland) · 2022Review
- Hypoxia-ischemia-mediated effects on neurodevelopmentally regulated cold-shock proteins in neonatal mice under strict temperature control.Pediatric research · 2022Article
- Deficits in Seizure Threshold and Other Behaviors in Adult Mice without Gross Neuroanatomic Injury after Late Gestation Transient Prenatal Hypoxia.Developmental neuroscience · 2022Article
- Resveratrol Improves Synaptic Plasticity in Hypoxic-Ischemic Brain Injury in Neonatal Mice via Alleviating SIRT1/NF-κB Signaling-Mediated Neuroinflammation.Journal of molecular neuroscience : MN · 2022Article
- Recent studies are focus on the new treatments for hypoxicischemic encephalopathy (HIE) and long-term outcomes in later childhood and adolescence in children with a history on HIE.Clinical and experimental pediatrics · 2021Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypoxic-ischemic encephalopathy (HIE) in term-born infants can lead to memory problems. The hippocampus is important for long-term episodic memory. The primary aim was to investigate the effect of HIE on hippocampal volumes in 9- to 10-year-old children. The secondary aim was to investigate the association between hippocampal volumes and previously found impaired memory and cognitive functions in the current cohort.
methodsIn total 26 children with mild HIE, 26 with moderate HIE, and 37 controls were included. The intelligence quotient (IQ) and memory were tested. A 3D-volumetric MRI was obtained. Brain segmentation was performed for hippocampal volumes and intracranial volume. The differences in hippocampal volumes, memory, and IQ between the groups were determined. Multivariable linear regression analyses were performed, including hippocampal volume as a percentage of intracranial volume as a dependent variable.
resultsSmaller hippocampal volumes were found in moderate HIE (p < 0.001), with a trend toward smaller volumes in mild HIE, compared to controls. In multivariable linear regression analysis, hippocampal volume as a percentage of intracranial volume was significantly associated with long-term visuospatial memory.
conclusionChildren with moderate HIE had smaller hippocampal volumes than controls, with a trend toward smaller volumes following mild HIE. Reduced hippocampal volumes were associated with poorer long-term visuospatial memory.
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