ArticleMolecular psychiatry2018
The hippocampal extracellular matrix regulates pain and memory after injury.
Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 88 citations in OpenAlex.
- Regional homogeneity alterations reflect pain and emotional dysregulation in adenomyosis.Annals of medicine · 2026Article
- Chronic joint pain drives sex-specific changes in hippocampal glutamatergic signaling and sleep.npj biomedical innovations · 2026Article
- 11-keto-β-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury.Journal of advanced research · 2026Article
- The Meaning of Pain in the Clinical Management of Patients With Disorders of Consciousness: Is It a Neglected Issue?European journal of pain (London, England) · 2026Review
- The extracellular matrix as a dynamic regulator of brain function and plasticity.Neurobiology of disease · 2026Review
- Simplified Procedure for Isolation and Culture of Neuronal Cells from Brains of Sickle Cell Mice.Cells · 2026Article
- Unravelling the Connection Between Reduced Mobility and Mild Cognitive Impairment in Chronic Pain Patients Through Cluster Analysis.Advances in experimental medicine and biology · 2026Article
- Evaluation of reserpine-induced fibromyalgia in mice: A comparative behavioral, neurochemical, and histological assessment of two doses.IBRO neuroscience reports · 2025Article
- Hippocampal Extracellular Matrix Protein Laminin β1 Regulates Neuropathic Pain and Pain-Related Cognitive Impairment.Neuroscience bulletin · 2025Article
- Cognitive impairment in tension-type headache is associated with altered hippocampal functional connectivity.iScience · 2025Article
- Cingulate retinoic acid signaling regulates neuropathic pain and comorbid anxiodepression via extracellular matrix homeostasis.The Journal of clinical investigation · 2025Article
- Review
- Article
- Decoding Alzheimer's Disease With Depression: Molecular Insights and Therapeutic Target.Journal of cellular and molecular medicine · 2025Article
- Article
- A comprehensive review of the supraspinal mechanisms of spinal cord stimulation on chronic pain and cognition.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Effect of Acupuncture on Functional Connectivity of the Limbic Network in Patients with Knee Osteoarthritis: A Resting State Functional Magnetic Resonance Imaging Study.Journal of pain research · 2025Article
- Peripheral inflammation is accompanied by cerebral hypoperfusion in mice.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Lysophosphatidylcholine induced by fat transplantation regulates hyperalgesia by affecting the dysfunction of ACC perineuronal nets.iScience · 2024Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Chronic pain poses a heavy burden for the individual and society, comprising personal suffering, comorbid psychiatric symptoms, cognitive decline, and disability. Treatment options are poor due in large part to pain centralization, where an initial injury can result in lasting CNS maladaptations. Hippocampal cellular plasticity in chronic pain has become a focus of study due to its roles in cognition, memory, and the experience of pain itself. However, the extracellular alterations that parallel and facilitate changes in hippocampal function have not been addressed to date. Here we show structural and biochemical plasticity in the hippocampal extracellular matrix (ECM) that is linked to behavioral, cellular, and synaptic changes in a mouse model of chronic pain. Specifically, we report deficits in working location memory that are associated with decreased hippocampal dendritic complexity, altered ECM microarchitecture, decreased ECM rigidity, and changes in the levels of key ECM components and enzymes, including increased levels of MMP8. We also report aberrations in long-term potentiation (LTP) and a loss of inhibitory interneuron perineuronal ECM nets, potentially accounting for the aberrations in LTP. Finally, we demonstrate that MMP8 is upregulated after injury and that its genetic downregulation normalizes the behavioral, electrophysiological, and extracellular alterations. By linking specific extracellular changes to the chronic pain phenotype, we provide a novel mechanistic understanding of pain centralization that provides new targets for the treatment of chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.