Evidence map›Paper›PMID 30254182›Full record

ArticleMolecular cancer therapeutics2018

Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers.

Joel D Maust, Christy L Frankowski-McGregor, Armand Bankhead, Diane M Simeone, Judith S Sebolt-Leopold

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joel D MaustDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.
Christy L Frankowski-McGregorDepartment of Radiology, University of Michigan Medical School, Ann Arbor, Michigan.
Armand BankheadDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan.
Diane M SimeoneDepartment of Surgery, University of Michigan Medical School, Ann Arbor, Michigan.
Judith S Sebolt-LeopoldDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan. jssl@med.umich.edu.
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Translational Research in GI CancerP50CA130810 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, DEAN E. · 2010 to 2016
$11.8M
INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
Design of MEK Inhibitor Regimens for the Treatment of Pancreatic CancerR01CA155198 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEOPOLD, JUDITH S · 2012 to 2016
$1.9M
NCI NIH HHS P30 CA046592NCI NIH HHS P50 CA130810NCI NIH HHS R01 CA155198NIGMS NIH HHS T32 GM007767
6 · The paper itself

Abstract

The ineffectiveness of chemotherapy in patients with pancreatic cancer highlights a critical unmet need in pancreatic cancer therapy. Two commonly mutated genes in pancreatic cancer,

Indexed as

AnimalsApoptosis Regulatory ProteinsCell Cycle CheckpointsCell Line, TumorCell ProliferationCyclin D1Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Cyclooxygenase 2Down-RegulationFemaleG1 PhaseHumansMice, NudeMitogen-Activated Protein Kinase KinasesPancreatic NeoplasmsApoptosis Regulatory ProteinsCyclin D1Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Cyclooxygenase 2Mitogen-Activated Protein Kinase KinasespalbociclibPDCD4 protein, humanPiperazinesProtein Kinase InhibitorsPyridinesPyridonesPyrimidinonesRetinoblastoma ProteinRNA-Binding Proteinstrametinib

Identifiers

PMID30254182
PMCPMC6279520
OpenAlexW2892605164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.