Evidence map›Paper›PMID 30254173›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Optimal protection against

Joseph M Benoun, Newton G Peres, Nancy Wang, Oanh H Pham, Victoria L Rudisill, Zachary N Fogassy, Paul G Whitney, Daniel Fernandez-Ruiz, Thomas Gebhardt, Quynh-Mai Pham and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 50 citations in OpenAlex.

  1. Single-Cell Profiling Identifies Skin-Resident Memory CD4European journal of immunology · 2026
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  17. Optimal generation of hepatic tissue-resident memory CD4 T cells requires IL-1 and IL-2.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. Article
  20. Frontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Joseph M BenounCenter for Comparative Medicine, University of California, Davis, CA 95616.ORCID 0000-0001-5979-4974
Newton G PeresDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Nancy WangDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Oanh H PhamCenter for Comparative Medicine, University of California, Davis, CA 95616.
Victoria L RudisillCenter for Comparative Medicine, University of California, Davis, CA 95616.
Zachary N FogassyCenter for Comparative Medicine, University of California, Davis, CA 95616.
Paul G WhitneyDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Daniel Fernandez-RuizDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Thomas GebhardtDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Quynh-Mai PhamDepartment of Immunology, University of Connecticut Health Center, Farmington, CT 06030.
Lynn PuddingtonDepartment of Immunology, University of Connecticut Health Center, Farmington, CT 06030.
Sammy BedouiDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Richard A StrugnellDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
Stephen J McSorleyCenter for Comparative Medicine, University of California, Davis, CA 95616; sjmcsorley@ucdavis.edu.ORCID 0000-0002-6363-3222
The University of Melbourne · AUUniversity of California, Davis · USUConn Health · US

Funding

Sustained adaptive immunity in the mucosaP01AI056172 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MCSORLEY, STEPHEN J · 2003 to 2017
$22.3M
Animal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3M
Target antigen identification to improve Salmonella vaccinationR01AI139410 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STEPHEN J MCSORLEY, Renee M Tsolis · 2018 to 2026
$2.9M
CD4 T cell responses to Chlamydia infectionR01AI103422 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCSORLEY, STEPHEN J · 2016 to 2019
$1.5M
NIAID NIH HHS P01 AI056172NIAID NIH HHS R01 AI103422NIAID NIH HHS R01 AI139410NIAID NIH HHS T32 AI060555
6 · The paper itself

Abstract

While CD4 Th1 cells are required for resistance to intramacrophage infections, adoptive transfer of Th1 cells is insufficient to protect against

Indexed as

AnimalsCells, CulturedFemaleImmunizationImmunologic MemoryLiverMiceMice, Inbred C57BLSalmonella InfectionsSalmonella typhimuriumTh1 CellsT-LymphocytesCD4 T cellprotective immunitySalmonella infectiontissue-resident memoryvaccines

Identifiers

PMID30254173
PMCPMC6187142
OpenAlexW2893390572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.