ArticleProceedings of the National Academy of Sciences of the United States of America2018
Single-molecule optical absorption imaging by nanomechanical photothermal sensing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 98 citations in OpenAlex.
- Stimulated Raman photothermal microscopy: theory and implementation.Advances in optics and photonics · 2026Article
- Chip Calorimetry for Single-Cell Analysis: Advances, Challenges, and Opportunities.Sensors (Basel, Switzerland) · 2026Review
- Single-Particle Photothermal Microscopy Using On-Chip Silicon Nitride Microring Resonators.The journal of physical chemistry. A · 2026Article
- Spatial-offset pump-probe imaging of nonradiative dynamics at optical resolution.Science advances · 2025Article
- Comparative analysis of nanomechanical resonators: sensitivity, response time, and practical considerations in photothermal sensing.Microsystems & nanoengineering · 2025Article
- Single 5-nm quantum dot detection via microtoroid optical resonator photothermal microscopy.Light, science & applications · 2024Article
- Article
- Ultrahigh-quality-factor micro- and nanomechanical resonators using dissipation dilution.Nature nanotechnology · 2024Review
- Three-dimensional thermophotonic super-resolution imaging by spatiotemporal diffusion reversal method.Science advances · 2023Article
- Photothermal Microscopy and Spectroscopy with Nanomechanical Resonators.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023Review
- Stimulated Raman photothermal microscopy toward ultrasensitive chemical imaging.Science advances · 2023Article
- Nanomechanical Photothermal Near Infrared Spectromicroscopy of Individual Nanorods.ACS photonics · 2023Article
- Nanoelectromechanical Infrared Spectroscopy with In Situ Separation by Thermal Desorption: NEMS-IR-TD.ACS sensors · 2023Article
- Mode specific dynamics for the acoustic vibrations of a gold nanoplate.Photoacoustics · 2023Article
- Gigahertz optoacoustic vibration in Sub-5 nm tip-supported nano-optomechanical metasurface.Nature communications · 2023Article
- Optically Probing the Chirality of Single Plasmonic Nanostructures and of Single Molecules: Potential and Obstacles.ACS photonics · 2022Review
- Nanomechanical Spectroscopy of 2D Materials.Nano letters · 2022Article
- Recent Advances in Nanomechanical Membrane-Type Surface Stress Sensors towards Artificial Olfaction.Biosensors · 2022Review
- Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles.International journal of nanomedicine · 2022Review
- Avoiding transduction-induced heating in suspended microchannel resonators using piezoelectricity.Microsystems & nanoengineering · 2021Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Absorption microscopy is a promising alternative to fluorescence microscopy for single-molecule imaging. So far, molecular absorption has been probed optically via the attenuation of a probing laser or via photothermal effects. The sensitivity of optical probing is not only restricted by background scattering but it is fundamentally limited by laser shot noise, which minimizes the achievable single-molecule signal-to-noise ratio. Here, we present nanomechanical photothermal microscopy, which overcomes the scattering and shot-noise limit by detecting the photothermal heating of the sample directly with a temperature-sensitive substrate. We use nanomechanical silicon nitride drums, whose resonant frequency detunes with local heating. Individual Au nanoparticles with diameters from 10 to 200 nm and single molecules (Atto 633) are scanned with a heating laser with a peak irradiance of 354 ± 45 µW/µm
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.