ArticleBlood2018
T-cell defects in patients with
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In one paragraph
Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 116 citations in OpenAlex.
- Autosomal dominant gain-of-function mutations in LCP1 cause a syndromic neutropenia and immunodeficiency.Genes & diseases · 2027Article
- Article
- Comprehensive Profiling of T- and B-Cell Receptor Repertoires Demonstrates Impaired Developmental and Activation of Adaptive Immunity in DOCK8 Deficiency.Journal of clinical immunology · 2026Article
- Loss of the actin remodeling protein Flightless-1 impairs CD8 and regulatory T cell function.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- The Arp2/3 complex is required for in situ haptotactic response of microglia to iC3b.EMBO reports · 2026Article
- Characterisation of a Leaky Splice-Site Mutation Associated with Phenotypic Diversity in Two Unrelated Patients with ARPC1B Deficiency.Journal of clinical immunology · 2026Article
- Molecular analysis and immunological characterization of a founder mutation causing ARPC1B deficiency.Genes and immunity · 2026Article
- Immune-related actinopathies at the cross-road of immunodeficiency, autoimmunity and autoinflammation.Nature reviews. Immunology · 2026Review
- Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain.Cell reports. Medicine · 2026Article
- Case Report: Sirolimus as management strategy for thrombocytopenia related to ARPC1B deficiency.Frontiers in immunology · 2026Article
- Atypical lymphoproliferations associated with germline genetic variants: a report of the 2024 EA4HP/SH lymphoma workshop.Virchows Archiv : an international journal of pathology · 2025Review
- The c.64 + 2 T > A Founder Variant Hits Home: Report on 14 Patients Expands the Phenotypic Landscape of Inherited ARPC1B Deficiency - a Comparative Analysis.Clinical reviews in allergy & immunology · 2025Article
- Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ-actin.Nature communications · 2025Article
- Inborn errors of immunity with atopic phenotypes in the allergy and immunology clinic: a practical review.Current opinion in allergy and clinical immunology · 2025Review
- Regulation of actin cytoskeletal dynamics in T cell development and function.Frontiers in immunology · 2025Review
- Aspartyl proteases target host actin nucleator complex protein to limit epithelial innate immunity.EMBO reports · 2024Article
- CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes.EMBO reports · 2024Article
- β-Actin G342D as a Cause of NK Cell Deficiency Impairing Lytic Synapse Termination.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- HIV-1 Mediated Cortical Actin Disruption Mirrors ARP2/3 Defects Found in Primary T Cell Immunodeficiencies.bioRxiv : the preprint server for biology · 2024Article
- Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B.Journal of cell science · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
46 authors at 18 institutions in 8 countries.
Immacolata BrigidaSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-0338-2230
Matteo ZoccolilloSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Maria Pia CicaleseSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Laurène PfajferINSERM, Unité Mixte de Recherche (UMR) 1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.
Federica BarzaghiPediatric Immunohematology, IRCCS, San Raffaele Scientific Institute, Milan, Italy.
Serena ScalaSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Carmen Oleaga-QuintasLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.
Jesus A Álvarez-ÁlvarezGroup of Primary Immunodeficiencies, Department of Microbiology & Parasitology, School of Medicine, University of Antioquia (UdeA), Medellín, Colombia.
Lucia SereniSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Stefania GiannelliSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Claudia SartiranaSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Francesca DionisioSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Luca PavesiDivision of Experimental Oncology, Unit of B-Cell Neoplasia, San Raffaele Scientific Institute, Milan, Italy.
Marta Benavides-NietoPediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Luca Basso-RicciSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Paola CapassoSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Benedetta MazziImmunogenetics Laboratory, HLA & Chimerism, Department of Immunohematology & Blood Transfusion, IRCCS Ospedale San Raffaele, Milano, Italy.
Jeremie RosainLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.
Nufar MarcusKipper Institute for Allergy and Immunology, Schneider Children's Medical Center of Israel, Petach Tikva, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Yu Nee LeePediatric Department A and the Immunology Services, "Edmond and Lily Safra" Children's Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Raz SomechPediatric Department A and the Immunology Services, "Edmond and Lily Safra" Children's Hospital, Jeffrey Modell Foundation Center, Sheba Medical Center, Tel Hashomer, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Massimo DeganoDivision of Immunology, Transplantation, and Infectious Diseases, Biocrystallography Unit, San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-0787-1883
Giuseppe RaiolaUnità Operativa Complessa di Pediatria, Azienda Ospedaliera "Pugliese-Ciaccio" di Catanzaro.
Roberta CaorsiUnità Operativa Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Paolo PiccoUnità Operativa Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Marcela Moncada VelezGroup of Primary Immunodeficiencies, Department of Microbiology & Parasitology, School of Medicine, University of Antioquia (UdeA), Medellín, Colombia.
Joelle KhouriehLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.
Andrés Augusto AriasGroup of Primary Immunodeficiencies, Department of Microbiology & Parasitology, School of Medicine, University of Antioquia (UdeA), Medellín, Colombia.ORCID 0000-0002-9478-8403
Aziz BousfihaClinical Immunology Unit, Department of Pediatrics, King Hassan II University, Ibn-Rochd Hospital, Casablanca, Morocco.
Thomas IssekutzDepartment of Pediatrics & Department of Microbiology-Immunology, Dalhousie University, Halifax, NS, Canada.
Andrew IssekutzDepartment of Pediatrics & Department of Microbiology-Immunology, Dalhousie University, Halifax, NS, Canada.
Bertrand BoissonLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.
Kerry DobbsLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-3432-3137
Anna VillaSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Angelo LombardoSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.
Benedicte NevenPediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Despina MoshousPediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Jean-Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.
José Luis FrancoGroup of Primary Immunodeficiencies, Department of Microbiology & Parasitology, School of Medicine, University of Antioquia (UdeA), Medellín, Colombia.ORCID 0000-0001-5664-6415
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Cristina ScielzoDivision of Experimental Oncology, Unit of B-Cell Neoplasia, San Raffaele Scientific Institute, Milan, Italy.
Stefano VolpiUnità Operativa Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Loïc DupréINSERM, Unité Mixte de Recherche (UMR) 1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.
Jacinta BustamanteLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.
Marco GattornoUnità Operativa Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Alessandro AiutiSan Raffaele Telethon Institute for Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-5398-1717
The San Raffaele Telethon Institute for Gene Therapy · ITInserm · FRIstituto Giannina Gaslini · ITUniversidad de Antioquia · COVita-Salute San Raffaele University · ITTel Aviv University · ILDalhousie University · CADélégation Paris 5 · FRNational Institutes of Health · USSan Raffaele University of Rome · ITUniversité Toulouse III - Paul Sabatier · FRUniversity of Rome Tor Vergata · ITAssistance Publique – Hôpitaux de Paris · FRAzienda Ospedaliera Pugliese Ciaccio · ITHoward Hughes Medical Institute · USInstitute of Genetic and Biomedical Research · ITIRCCS Ospedale San Raffaele · ITUniversity of Hassan II Casablanca · MA
Funding
Characterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MAbstract
ARPC1B is a key factor for the assembly and maintenance of the ARP2/3 complex that is involved in actin branching from an existing filament. Germline biallelic mutations in
Indexed as
Germ-Line MutationActin-Related Protein 2-3 ComplexFemaleHomozygoteHumansImmunologic Deficiency SyndromesMaleModels, MolecularPedigreeProtein ConformationSevere Combined ImmunodeficiencyT-LymphocytesActin-Related Protein 2-3 ComplexARPC1B protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.