Evidence map›Paper›PMID 30254118›Full record

ArticlemBio2018

CdrA Interactions within the Pseudomonas aeruginosa Biofilm Matrix Safeguard It from Proteolysis and Promote Cellular Packing.

Courtney Reichhardt, Cynthis Wong, Daniel Passos da Silva, Daniel J Wozniak, Matthew R Parsek

Abstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Review
  2. Article
  3. A cold-responsiveApplied and environmental microbiology · 2026
    Article
  4. Molecular Mechanisms Underlying the Pathogenicity ofMedicina (Kaunas, Lithuania) · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Coacervate Dense Phase Displaces Surface-EstablishedJournal of the American Chemical Society · 2024
    Article
  10. Article
  11. Antibiotics (Basel, Switzerland) · 2024
    Review
  12. Biofilm · 2024
    Article
  13. Differences in Biofilm Formation ofFoods (Basel, Switzerland) · 2024
    Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Bacterial respiratory inhibition triggers dispersal ofApplied and environmental microbiology · 2023
    Article
  19. Article
  20. Microstructural and Rheological Transitions in Bacterial Biofilms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Courtney ReichhardtDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Cynthis WongDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Daniel Passos da SilvaDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Daniel J WozniakDepartments of Microbial Infection and Immunity, Microbiology, The Ohio State University, Columbus, Ohio, USA.
Matthew R ParsekDepartment of Microbiology, University of Washington, Seattle, Washington, USA parsem@u.washington.edu.

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
Revisiting alginate paradigmsR01AI134895 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2018 to 2022
$2.5M
Pseudomonas biofilms and immunityR01AI097511 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2013 to 2017
$1.9M
NIAID NIH HHS R01 AI077628NIAID NIH HHS R01 AI097511NIAID NIH HHS R01 AI134895NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

Biofilms are robust multicellular aggregates of bacteria that are encased in an extracellular matrix. Different bacterial species have been shown to use a range of biopolymers to build their matrices.

Indexed as

Gene Expression Regulation, BacterialAdhesins, BacterialBacterial ProteinsBiofilmsExtracellular Polymeric Substance MatrixMetalloendopeptidasesPeptide HydrolasesPolysaccharides, BacterialProteolysisPseudomonas aeruginosaAdhesins, BacterialBacterial ProteinsCdrA protein, Pseudomonas aeruginosaMetalloendopeptidasesPeptide HydrolasesPolysaccharides, Bacterialpseudolysin, Pseudomonas aeruginosabiofilmCdrAelastaseexopolysaccharidesPseudomonas aeruginosaPsl

Identifiers

PMID30254118
PMCPMC6156197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.