ArticlemBio2018
Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease.
Open access · goldAbstract read
In one paragraph
Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 43 citations in OpenAlex.
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- Minimal Association Between Immunoglobulin A Coating and Gut Microbiota Alterations Induced by High-Fat Diets with Distinct Fatty Acid Compositions.International journal of molecular sciences · 2026Article
- Virulence factors ofFrontiers in microbiology · 2026Article
- Loss of cPLA2α function attenuates inflammation and epithelial thickening in a mouse model ofCurrent research in microbial sciences · 2026Article
- The Major Outer Membrane Protein P5 Binds Vitronectin to Mediate Serum Resistance in Nontypeable Haemophilus influenzae.The Journal of infectious diseases · 2025Article
- A 5'-UTR cis-acting RNA element targeted by RNase III is essential for DNA simple sequence repeat-dependent phase variation in Haemophilus influenzae.Nucleic acids research · 2025Article
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- Metronidazole response profiles of Gardnerella species are congruent with phylogenetic and comparative genomic analyses.Genome medicine · 2025Article
- Bacterial acquisition of host fatty acids has far-reaching implications on virulence.Microbiology and molecular biology reviews : MMBR · 2024Review
- Effects of fluid shear stress on oral biofilm formation and composition and the transcriptional response of Streptococcus gordonii.Molecular oral microbiology · 2024Article
- Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signalling networks.Proceedings. Biological sciences · 2024Article
- Multimodal evaluation of drug antibacterial activity reveals cinnamaldehyde analog anti-biofilm effects againstBiofilm · 2024Article
- Pleiotropy alleviates the fitness costs associated with resource allocation trade-offs in immune signaling networks.bioRxiv : the preprint server for biology · 2023Article
- Article
- Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment.Microbiology spectrum · 2023Article
- Imipenem heteroresistance but not tolerance inFrontiers in microbiology · 2023Article
- The natural history and genetic diversity of Haemophilus influenzae infecting the airways of adults with cystic fibrosis.Scientific reports · 2022Article
- Article
- An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim.Genome biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 2 countries.
Javier Moleres *Instituto de Agrobiotecnología, CSIC-Universidad Pública Navarra-Gobierno Navarra, Mutilva, Spain.
Ariadna Fernández-Calvet *Instituto de Agrobiotecnología, CSIC-Universidad Pública Navarra-Gobierno Navarra, Mutilva, Spain.
Rachel L EhrlichDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Sara MartíCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Lucía Pérez-RegidorDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas, CIB-CSIC, Madrid, Spain.
Begoña EubaInstituto de Agrobiotecnología, CSIC-Universidad Pública Navarra-Gobierno Navarra, Mutilva, Spain.
Irene Rodríguez-ArceInstituto de Agrobiotecnología, CSIC-Universidad Pública Navarra-Gobierno Navarra, Mutilva, Spain.
Sergey BalashovDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Ester CuevasPneumology Department, Hospital Universitari Bellvitge, University of Barcelona, IDIBELL, Barcelona, Spain.
Josefina LiñaresCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Carmen ArdanuyCentro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Sonsoles Martín-SantamaríaDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas, CIB-CSIC, Madrid, Spain.
Garth D EhrlichDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
Joshua Chang MellDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA jcm385@drexel.edu juncal.garmendia@unavarra.es.
Junkal GarmendiaInstituto de Agrobiotecnología, CSIC-Universidad Pública Navarra-Gobierno Navarra, Mutilva, Spain jcm385@drexel.edu juncal.garmendia@unavarra.es.
Agrobiotechnology Institute · ESInstitute for Molecular Medicine · USBellvitge University Hospital · ESCentro de Investigaciones Biológicas Margarita Salas · ESUniversitat de Barcelona · ESCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESDrexel University · US
Funding
MAPP Research NetworkU01DK082316 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LANDIS, J RICHARD · 2008 to 2018
$17.2MMOLECULAR ANALYSIS OF PATHOGENS IN OTITIS MEDIA BY PCRR01DC002148 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EHRLICH, GARTH D. · 1994 to 2017
$6.5MNIDCD NIH HHS R01 DC002148NIDDK NIH HHS U01 DK082316
Abstract
Tracking bacterial evolution during chronic infection provides insights into how host selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen nontypeable
Indexed as
Adaptation, BiologicalAgedAged, 80 and overBacterial Outer Membrane ProteinsComputational BiologyFatty Acid Transport ProteinsGenetic VariationGenome, BacterialHaemophilus InfectionsHaemophilus influenzaeHumansLongitudinal StudiesMiddle AgedMolecular Docking SimulationMutationPneumonia, BacterialBacterial Outer Membrane ProteinsFatty Acid Transport Proteinsadaptive evolutionantagonistic pleiotropicCEACAM1chronic obstructive pulmonary diseasecomparative genomicsconvergent evolutionFadL/OmpP1free fatty acidsHaemophilus influenzaein situ evolution
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.