Evidence map›Paper›PMID 30253780›Full record

ArticleJournal of neuroinflammation2018

Genetically enhancing the expression of chemokine domain of CX

Shane M Bemiller, Nicole M Maphis, Shane V Formica, Gina N Wilson, Crystal M Miller, Guixiang Xu, Olga N Kokiko-Cochran, Ki-Wook Kim, Steffen Jung, Judy L Cannon and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Review
  3. Beyond Neuroinflammation: Microglia at the Crossroads of Amyloid, Tau, and Neurodegeneration in Alzheimer's Disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and Pathogenesis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  13. Article
  14. Microglia Biomarkers in Alzheimer's Disease.Molecular neurobiology · 2021
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Intersection of pathological tau and microglia at the synapse.Acta neuropathologica communications · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Shane M BemillerDepartment of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Nicole M MaphisDepartment of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM, 87113, USA.
Shane V FormicaDepartment of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Gina N WilsonKent State University, Kent, OH, 44242, USA.
Crystal M MillerDepartment of Neurosciences, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.
Guixiang XuStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Olga N Kokiko-CochranDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Ki-Wook KimDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO, 63110, USA.
Steffen JungDepartment of Immunology, Weizmann Institute of Science, 76100, Rehovot, Israel.
Judy L CannonDepartment of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM, 87113, USA.
Samuel D CrishDepartment of Pharmacology, Northeast Ohio Medical School, Rootstown, OH, 44272, USA.
Astrid E CardonaDepartment of Biology, University of Texas San Antonio, West Campus/Tobin lab MBT 1.216, San Antonio, TX, 78249, USA.
Bruce T LambStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Kiran BhaskarDepartment of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM, 87113, USA. kbhaskar@salud.unm.edu.ORCID http://orcid.org/0000-0001-6064-8106
Cleveland Clinic · USUniversity of New Mexico · USIndiana University School of MedicineKent State University · USNortheast Ohio Medical University · USThe Ohio State University · USThe University of Texas at San Antonio · USWashington University in St. Louis · USWeizmann Institute of Science · IL

Funding

VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Central and Peripheral Roles of TREM2 in Alzheimer's DiseaseRF1AG051495 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LAMB, BRUCE T, LANDRETH, GARY E. · 2015 to 2015
$3.6M
Modifiers of Beta-Amyloid Metabolism and DepositionR01AG023012 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI LAMB, BRUCE T · 2004 to 2013
$2.9M
Role of C-type Lectin Receptors in Myeloid Plasticity in NeurocysticercosisR01NS078501 · NINDS · UNIVERSITY OF TEXAS SAN ANTONIO · PI CARDONA, ASTRID E · 2012 to 2016
$1.9M
Axonopathy in GlaucomaR01EY022358 · NEI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI CRISH, SAMUEL D · 2012 to 2016
$1.9M
Role of CX3CR1 in adaptive immunity during autoimmune encephalomyelitisSC1GM095426 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI CARDONA, ASTRID E · 2012 to 2016
$1.5M
The role of inflammasome signaling in tauopathiesR01NS083704 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BHASKAR, KIRAN · 2014 to 2018
$1.4M
The role of microglial-and neuron-specific MyD88 signaling in tauopathiesR21NS077089 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BHASKAR, KIRAN · 2012 to 2013
$418k
Light-based regulation of autophagy processing to target pathological forms of tauR21NS093442 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BHASKAR, KIRAN, WEICK, JASON P · 2016 to 2017
$417k
The role of TREM2-positive monocytes in Alzheimer's diseaseF31AG050409 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI BEMILLER, SHANE · 2015 to 2015
$21k
Alzheimer's Association NIRG-11-204995American Health Assistance Foundation AHAF0311Indiana Clinical and Translational Sciences Institute UL1TR001108NCATS NIH HHS UL1 TR001108NEI NIH HHS R01 EY022358NEI NIH HHS R01EY022358NIA NIH HHS F31 AG050409NIA NIH HHS F31AG050409-01A1NIA NIH HHS P50 AG005142NIA NIH HHS R01 AG023012NIA NIH HHS R01AG023012 and RF1AG051495NIA NIH HHS RF1 AG051495NIGMS NIH HHS P20 GM109089NIGMS NIH HHS SC1 GM095426NIGMS NIH HHS SC1GM095426NINDS NIH HHS R01NS047804NINDS NIH HHS R01 NS078501NINDS NIH HHS R01NS078501NINDS NIH HHS R01 NS083704NINDS NIH HHS R01NS083704NINDS NIH HHS R21 NS077089NINDS NIH HHS R21NS077089NINDS NIH HHS R21 NS093442NINDS NIH HHS R21NS093442U.S. Department of Defense W81XWH-13 MRPRA-CSRA
6 · The paper itself

Abstract

backgroundFractalkine (CX

methodsWe used transgenic mice lacking endogenous Cx

resultsFirst, increased basal tau levels accompanied microglial activation in Cx

conclusionsCollectively, our data suggest that overexpression of only chemokine domain of CX

Indexed as

AnimalsAntigens, DifferentiationCalcium-Binding ProteinsChemokine CX3CL1Cognition DisordersCytokinesDisease Models, AnimalGene Expression RegulationLipopolysaccharidesMaze LearningMiceMice, TransgenicMicrofilament ProteinsMicrogliaMutationTauopathiesAif1 protein, mouseAntigens, DifferentiationCalcium-Binding ProteinsChemokine CX3CL1CytokinesLipopolysaccharidesMapt protein, mouseMicrofilament Proteinsmonocyte-macrophage differentiation antigentau ProteinsAlzheimer’s diseaseCX3CL1CX3CR1MicrogliaNeuroinflammationTauTauopathies

Identifiers

PMID30253780
PMCPMC6154806
OpenAlexW2893176204

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.