Evidence map›Paper›PMID 30253757›Full record

ArticleBMC biology2018

Brevican "nets" voltage-gated calcium channels at the hair cell ribbon synapse.

Thomas M Coate, Katherine Conant

Open access · goldAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Thomas M CoateDepartment of Biology, Georgetown University, 37th and O St. NW, Washington, DC, 20007, USA. Thomas.Coate@georgetown.edu.
Katherine ConantDepartment of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road, Washington, DC, 20007, USA. kec84@georgetown.edu.ORCID 0000-0003-3882-9810
Georgetown University · US

Funding

Cellular and Molecular Mechanisms of Cochlear InnervationR01DC016595 · NIDCD · GEORGETOWN UNIVERSITY · PI Thomas M Coate · 2018 to 2026
$4.4M
Perineuronal proteolysis and circuit dysfunction in HANDR01NS108810 · NINDS · GEORGETOWN UNIVERSITY · PI CONANT, KATHERINE E, MAGUIRE-ZEISS, KATHLEEN ANNE · 2018 to 2022
$1.9M
Wiring of Spiral Ganglion Neurons and Auditory Hair Cells by Secreted SemaphorinsR00DC013107 · NIDCD · GEORGETOWN UNIVERSITY · PI COATE, THOMAS M · 2014 to 2017
$956k
NIDCD NIH HHS R00 DC013107NIDCD NIH HHS R01 DC016595NINDS NIH HHS R01 NS108810
6 · The paper itself

Abstract

During hearing in mammals, "sensorineural" inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at specialized synapses known as "ribbon synapses". New findings published here in BMC Biology by Sonntag and colleagues indicate a role for the proteoglycan Brevican in forming perineurounal net (PNN) baskets at these synapses and controlling the spatial distribution of presynaptic voltage-gated calcium channels that regulate glutamate release. These findings may provide insight into the mechanism by which individual ribbon synapses within a single hair cell can function in an independent manner to facilitate hearing within a broad dynamic range.

Indexed as

BrevicanCalciumAnimalsExtracellular MatrixHairSynapsesBrevicanCalcium

Identifiers

PMID30253757
PMCPMC6156861
OpenAlexW2890013297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.