ArticleBMC infectious diseases2018
Resistant Streptococcus pneumoniae strains in children with acute otitis media- high risk of persistent colonization after treatment.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Pooled it
- Effect of Biannual Azithromycin to Children under 5 Years on the Carriage of Respiratory Pathogens among Children Aged 7-11 Years.The American journal of tropical medicine and hygiene · 2023Trial
- Incidence and determinants of antibiotic use by age two: a prospective cohort study.medRxiv : the preprint server for health sciences · 2026Article
- Global Antimicrobial Non-Susceptibility Patterns ofInfection and drug resistance · 2026Review
- Respiratory pathogens in infants and young children with acute respiratory illness: a prospective cohort study, China, 2023-2024.Frontiers in public health · 2025Article
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- The Molecular Epidemiology of Pneumococcal Strains Isolated from the Nasopharynx of Preschool Children 3 Years after the Introduction of the PCV Vaccination Program in Poland.International journal of molecular sciences · 2023Article
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- Serotype distribution and antimicrobial resistance ofIranian journal of microbiology · 2022Article
- Molecular Characterization of Predominant Serotypes, Drug Resistance, and Virulence Genes ofFrontiers in microbiology · 2022Article
- The application value of metagenomic next-generation sequencing in children with invasive pneumococcal disease.Translational pediatrics · 2021Article
- From Evidence to Clinical Guidelines in Antibiotic Treatment in Acute Otitis Media in Children.Antibiotics (Basel, Switzerland) · 2021Review
- Nasopharyngeal carriage rates and serotype distribution ofAccess microbiology · 2021Article
- Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019.International journal of pediatric otorhinolaryngology · 2020Review
- Vinpocetine SuppressesJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Article
- Article
- Ruthenium Chloride-Induced Oxidative Cyclization of Trans-Resveratrol to (±)-ε-Viniferin and Antimicrobial and Antibiofilm Activity AgainstFrontiers in pharmacology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite advances in the development of pneumococcal conjugate vaccines, acute otitis media (AOM) is a common childhood infection, caused mainly by Streptococcus pneumoniae. It has been suggested that persistence of pneumococcal nasopharyngeal carriage is a risk factor for subsequent recurrent infections.
methodsIn this study we evaluate the relationship between 55 pneumococcal strains obtained from nasopharynx/oropharynx (NP/OP) and middle ear fluid (MEF) of 62 children, aged between 1 and 16 years, during AOM (including recurrent/treatment failure AOM, and post-treatment visits), based on their phenotypic and genotypic characteristics performed by analyses of serotype, antibiotic susceptibility patterns and multilocus sequence typing.
resultsS.pneumoniae was isolated from 27.4% of MEF samples; it constituted 43.6% of all positive bacterial samples from MEF samples. There was statistically significant concordance between isolation from the MEF sample and NP/OP colonization by S. pneumoniae (p < 0.0001). During post-treatment visits S.pneumoniae was isolated from 20.8% of children; 91% of them were positive in pneumococcal NP/OP culture during AOM. The serotypes belonging to 10- and 13-valent pneumococcal conjugated vaccines constituted 84% and 92% of the strains, respectively. Multidrug resistance was found in 84% of the strains. According to multivariate analysis, pneumococcal colonization after antibiotic therapy was significantly associated with shorter length of therapy in children with bilateral AOM.
conclusionsHigh persistent prevalence of antibiotic-resistant S.pneumoniae strains in children with AOM after unsuccessful bacterial eradication may presumably be regarded as a predisposing factor of infection recurrence.
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