ArticleBMC genomics2018
Genome-wide analyses of genes encoding FK506-binding proteins reveal their involvement in abiotic stress responses in apple.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Deciphering intra-connectivity of gene network response to drought and salinity in apple.Frontiers in plant science · 2026Article
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- Genome-Wide Analysis of Tea FK506-Binding Proteins (FKBPs) Reveals ThatInternational journal of molecular sciences · 2025Article
- Genome-wide analysis of the FKBP gene family and the potential role of GhFKBP 13 in chloroplast biogenesis in upland cotton.BMC genomics · 2025Article
- Cotton Bollworm (H. armigera) Effector PPI5 Targets FKBP17-2 to Inhibit ER Immunity and JA/SA Responses, Enhancing Insect Feeding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Genome-wide identification and expression analyses ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Pan-genome survey ofFrontiers in microbiology · 2024Article
- Genome-wide association study and pathway analysis to decipher loci associated with Fusarium ear rot resistance in tropical maize germplasm.Genetic resources and crop evolution · 2024Article
- High Arctic seawater and coastal soil microbiome co-occurrence and composition structure and their potential hydrocarbon biodegradation.ISME communications · 2024Article
- Identification of the AHP family reveals their critical response to cytokinin regulation during adventitious root formation in apple rootstock.Frontiers in plant science · 2024Article
- Article
- Genome-Wide Identification and Analysis of FKBP Gene Family in Wheat (International journal of molecular sciences · 2022Article
- MicroRNAs expression profiles in early responses to different levels of water deficit inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Genome-wide characterization of FK506-binding proteins, parvulins and phospho-tyrosyl phosphatase activators in wheat and their regulation by heat stress.Frontiers in plant science · 2022Article
- Cloning, sequencing, and expression analysis of 32 NAC transcription factors (MdNAC) in apple.PeerJ · 2020Article
- Isolation, sequencing, and expression analysis of 30 AP2/ERF transcription factors in apple.PeerJ · 2020Article
- Genome-wide identification, expression, and interaction analysis for ovate family proteins in peach.Molecular biology reports · 2019Article
- Apple whole genome sequences: recent advances and new prospects.Horticulture research · 2019Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe FK506-binding proteins (FKBPs) play diverse roles in numerous critical processes for plant growth, development, and abiotic stress responses. However, the FKBP gene family in the important fruit crop apple (Malus × domestica Borkh.) has not been studied as thoroughly as in other species. Our research objective was to investigate the mechanisms by which apple FKBPs enable apple plants to tolerate the effects of abiotic stresses.
resultsUsing bioinformatics-based methods, RT-PCR, and qRT-PCR technologies, we identified 38 FKBP genes and cloned 16 of them in the apple genome. The phylogenetic analysis revealed three major groups within that family. The results from sequence alignments, 3-D structures, phylogenetics, and analyses of conserved domains indicated that apple FKBPs are highly and structurally conserved. Furthermore, genomics structure analysis showed that those genes are also highly and structurally conserved in several other species. Comprehensive qRT-PCR analysis found various expression patterns for MdFKBPs in different tissues and in plant responses to water-deficit and salt stresses. Based on the results from interaction network and co-expression analyses, we determined that the pairing in the MdFKBP62a/MdFKBP65a/b-mediated network is involved in water-deficit and salt-stress signaling, both of which are uniformly up-regulated through interactions with heat shock proteins in apple.
conclusionsThese results provide new insight for further study of FKBP genes and their functions in abiotic stress response and multiple metabolic and physiological processes in apple.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.