Evidence map›Paper›PMID 30253306›Full record

ArticleMedical image analysis2018

Quantitative 3D Analysis of Coronary Wall Morphology in Heart Transplant Patients: OCT-Assessed Cardiac Allograft Vasculopathy Progression.

Zhi Chen, Michal Pazdernik, Honghai Zhang, Andreas Wahle, Zhihui Guo, Helena Bedanova, Josef Kautzner, Vojtech Melenovsky, Tomas Kovarnik, Milan Sonka

Registry-linked trialAbstract read
In one paragraph

Article in Medical image analysis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04193306 (ACAV), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04193306 phase4unknown statusnot on this mapstarted 2019, after this paper: background citation

ACAV: Efficacy and Safety Of Alirocumab to Prevent Early Cardiac Allograft Vasculopathy in Recent Heart Transplant Recipients

TypeinterventionalSponsorInstitute for Clinical and Experimental MedicineRan2019 to 2025Enrolled126ConditionsCardiac Allograft VasculopathyArmsAlirocumab, Placebo
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhi ChenIowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA 52242, USA.
Michal PazdernikInstitute of Clinical and Experimental Medicine (IKEM) in Prague, Czech Republic.
Honghai ZhangIowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA 52242, USA.
Andreas WahleIowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA 52242, USA.
Zhihui GuoIowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA 52242, USA.
Helena BedanovaCardiovascular and Transplantation Surgery Center, Department of Cardiovascular Diseases, St. Annes University Hospital and Masaryk University Brno, Czech Republic.
Josef KautznerInstitute of Clinical and Experimental Medicine (IKEM) in Prague, Czech Republic.
Vojtech MelenovskyInstitute of Clinical and Experimental Medicine (IKEM) in Prague, Czech Republic.
Tomas Kovarnik2nd Department of Medicine - Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague & General University Hospital in Prague, Czech Republic.
Milan SonkaIowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA 52242, USA. Electronic address: milan-sonka@uiowa.edu.

Funding

Graph-Based Medical Image Segmentation in 3D and 4DR01EB004640 · NIBIB · UNIVERSITY OF IOWA · PI BUATTI, JOHN M, SONKA, MILAN · 2006 to 2022
$6.1M
NIBIB NIH HHS R01 EB004640
6 · The paper itself

Abstract

Cardiac allograft vasculopathy (CAV) accounts for about 30% of all heart-transplant (HTx) patient deaths. For patients at high risk for CAV complications after HTx, therapy must be initiated early to be effective. Therefore, new phenotyping approaches are needed to identify such HTx patients at the earliest possible time. Coronary optical coherence tomography (OCT) images were acquired from 50 HTx patients 1 and 12 months after HTx. Quantitative analysis of coronary wall morphology used LOGISMOS segmentation strategy to simultaneously identify three wall-layer surfaces for the entire pullback length in 3D: luminal, outer intimal, and outer medial surfaces. To quantify changes of coronary wall morphology between 1 and 12 months after HTx, the two pullbacks were mutually co-registered. Validation of layer thickness measurements showed high accuracy of performed layer analyses with layer thickness measures correlating well with manually-defined independent standard (R

Indexed as

Heart TransplantationAllograftsCoronary VesselsHumansTime FactorsTomography, Optical CoherenceCardiac allograft vasculopathy (CAV)CAV predictionCAV progressionLOGISMOSoptical coherence tomography (OCT)

Identifiers

PMID30253306
PMCPMC6237624

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.