Evidence map›Paper›PMID 30253051›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019

Better graft outcomes from offspring donor kidneys among living donor kidney transplant recipients in the United States.

Courtenay M Holscher, Xun Luo, Allan B Massie, Tanjala S Purnell, Jacqueline M Garonzik Wang, Sunjae Bae, Macey L Henderson, Fawaz Al Ammary, Shane E Ottman, Dorry L Segev

Open access · hybridAbstract read
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In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. It's All Relative: Donor-Recipient Relationships, Disease Heritability, and Kidney Transplant Outcomes.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Courtenay M HolscherDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-5808-5954
Xun LuoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-0244-9832
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Tanjala S PurnellDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jacqueline M Garonzik WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Sunjae BaeDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-0098-8816
Macey L HendersonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Fawaz Al AmmaryDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Shane E OttmanDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USNational Marrow Donor Program · US

Funding

Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Patient-Centered Strategies to Reduce Disparities in Access to Kidney TransplantationK01HS024600 · AHRQ · JOHNS HOPKINS UNIVERSITY · PI PURNELL, TANJALA · 2016 to 2020
$786k
Technological Innovations for Live Kidney Donor Follow-up Care ManagementK01DK114388 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEVAN, MACEY LEIGH · 2017 to 2021
$720k
Trajectory of post-donation renal function in living kidney donorsF32DK109662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HOLSCHER, COURTENAY · 2016 to 2018
$232k
AHRQ HHS K01 HS024600American College of SurgeonsNIDDK NIH HHS F32 DK109662NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K01 DK114388NIDDK NIH HHS K24 DK101828
6 · The paper itself

Abstract

A recent study reported that kidney transplant recipients of offspring living donors had higher graft loss and mortality. This seemed counterintuitive, given the excellent HLA matching and younger age of offspring donors; we were concerned about residual confounding and other study design issues. We used Scientific Registry of Transplant Recipients data 2001-2016 to evaluate death-censored graft failure (DCGF) and mortality for recipients of offspring versus nonoffspring living donor kidneys, using Cox regression models with interaction terms. Recipients of offspring kidneys had lower DCGF than recipients of nonoffspring kidneys (15-year cumulative incidence 21.2% vs 26.1%, P < .001). This association remained after adjustment for recipient and transplant factors (adjusted hazard ratio [aHR] =

Indexed as

Living DonorsTransplant RecipientsAdultAgedBlack or African AmericanFemaleGraft RejectionGraft SurvivalHLA AntigensHumansIncidenceKidneyKidney Failure, ChronicKidney TransplantationMaleMiddle AgedHLA Antigensdonors and donation: livingethnicity/racegraft survivalhealth services and outcomes researchkidney transplantation: living donorkidney transplantation/nephrology

Identifiers

PMID30253051
PMCPMC6310629
OpenAlexW2893500930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.