ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019
Structural heteropolysaccharides as air-tight sealants of the human pleura.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Plant heteropolysaccharides and their bioadhesion to animal glycocalyx visualized at the nanoscale.Communications biology · 2026Article
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- Effect of Chitosan on Rheological, Mechanical, and Adhesive Properties of Pectin-Calcium Gel.Marine drugs · 2023Article
- Biomechanics of a Plant-Derived Sealant for Corneal Injuries.Translational vision science & technology · 2023Article
- 3D stimulated Raman spectral imaging of water dynamics associated with pectin-glycocalyceal entanglement.Biomedical optics express · 2023Article
- Serosal Adhesion Ex Vivo of Hydrogels Prepared from Apple Pectin Cross-Linked with FeInternational journal of molecular sciences · 2023Article
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- Kinetics of Pectin Biopolymer Facial Erosion Characterized by Fluorescent Tracer Microfluidics.Polymers · 2022Article
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- Improved outcomes utilizing a novel pectin-based pleural sealant following acute lung injury.The journal of trauma and acute care surgery · 2020Article
- An organosynthetic soft robotic respiratory simulator.APL bioengineering · 2020Article
- Water-Dependent Blending of Pectin Films: The Mechanics of Conjoined Biopolymers.Molecules (Basel, Switzerland) · 2020Article
- Pectin biopolymer mechanics and microstructure associated with polysaccharide phase transitions.Journal of biomedical materials research. Part A · 2020Article
- Analysis of pectin biopolymer phase states using acoustic emissions.Carbohydrate polymers · 2020Article
- The Effect of Calcium on the Cohesive Strength and Flexural Properties of Low-Methoxyl Pectin Biopolymers.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Pulmonary "air leaks," typically the result of pleural injury caused by lung surgery or chest trauma, result in the accumulation of air in the pleural space (pneumothorax). Air leaks are a major source of morbidity and prolonged hospitalization after pulmonary surgery. Previous work has demonstrated structural heteropolysaccharide (pectin) binding to the mouse pleural glycocalyx. The similar lectin-binding characteristics and ultrastructural features of the human and mouse pleural glycocalyx suggested the potential application of these polymers in humans. To investigate the utility of pectin-based polymers, we developed a simulacrum using freshly obtained human pleura. Pressure-decay leak testing was performed with an inflation maneuver that involved a 3 s ramp to a 3 s plateau pressure; the inflation was completely abrogated after needle perforation of the pleura. Using nonbiologic materials, pressure-decay leak testing demonstrated an exponential decay with a plateau phase in materials with a Young's modulus less than 5. In human pleural testing, the simulacrum was used to test the sealant function of four mixtures of pectin-based polymers. A 50% high-methoxyl pectin and 50% carboxymethylcellulose mixture demonstrated no sealant failures at transpleural pressures of 60 cmH
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