Evidence map›Paper›PMID 30252956›Full record

ArticleAmerican journal of hematology2019

Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.

Elisabetta Beneduce, Alessandro Matte, Luigia De Falco, Serge Mbiandjeu, Deborah Chiabrando, Emanuela Tolosano, Enrica Federti, Sara Petrillo, Narla Mohandas, Angela Siciliano and 5 more

Open access · greenAbstract read
In one paragraph

Article in American journal of hematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  14. Nrf2 Plays a Key Role in Erythropoiesis during Aging.Antioxidants (Basel, Switzerland) · 2024
    Article
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  20. STAT5 as a Key Protein of Erythropoietin Signalization.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Elisabetta BeneduceDepartment of Medicine, University of Verona, AOUI Verona, Verona, Italy.
Alessandro MatteDepartment of Medicine, University of Verona, AOUI Verona, Verona, Italy.
Luigia De FalcoDepartment of Biochemistry, Federico II University, Naples, Italy.
Serge MbiandjeuDepartment of Medicine, University of Verona, AOUI Verona, Verona, Italy.
Deborah ChiabrandoDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Emanuela TolosanoDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Enrica FedertiDepartment of Medicine, University of Verona, AOUI Verona, Verona, Italy.
Sara PetrilloDepartment of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Narla MohandasNew York Blood Center, New York, New York.
Angela SicilianoDepartment of Medicine, University of Verona, AOUI Verona, Verona, Italy.
Wilson BabuDepartment of Medicine, University of Verona, AOUI Verona, Verona, Italy.
Vijay MenonDepartment of Cell, Development and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
Saghi GhaffariDepartment of Cell, Development and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
Achille IolasconDepartment of Biochemistry, Federico II University, Naples, Italy.
Lucia De FranceschiDepartment of Medicine, University of Verona, AOUI Verona, Verona, Italy.ORCID 0000-0001-7093-777X
University of Verona · ITUniversity of Turin · ITFederico II University Hospital · ITIcahn School of Medicine at Mount Sinai · USNew York Blood Center · US

Funding

(PQ5) Mitochondria in Leukemic Stem Cell Disease ProgressionR01CA205975 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GHAFFARI, SAGHI · 2016 to 2025
$3.9M
Mitochondria in the Regulation of Terminal ErythropoiesisR01HL136255 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAGHI GHAFFARI · 2017 to 2026
$3.8M
NCI NIH HHS R01 CA205975NHLBI NIH HHS R01 HL136255
6 · The paper itself

Abstract

The signaling cascade induced by the interaction of erythropoietin (EPO) with its receptor (EPO-R) is a key event of erythropoiesis. We present here data indicating that Fyn, a Src-family-kinase, participates in the EPO signaling-pathway, since Fyn

Indexed as

AnimalsAutophagyDoxorubicinErythroblastsErythropoiesisFemaleJanus Kinase 2MiceMice, KnockoutNF-E2-Related Factor 2Oxidation-ReductionOxidative StressPhenylhydrazinesPhosphorylationProtein Processing, Post-TranslationalProto-Oncogene Proteins c-fynDoxorubicinFyn protein, mouseJak2 protein, mouseJanus Kinase 2mTOR protein, mouseNfe2l2 protein, mouseNF-E2-Related Factor 2phenylhydrazinePhenylhydrazinesProto-Oncogene Proteins c-fynReactive Oxygen SpeciesReceptors, ErythropoietinSirolimusSTAT5 Transcription FactorTOR Serine-Threonine Kinases

Identifiers

PMID30252956
PMCPMC7213426
OpenAlexW2893367785

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.