ArticleAlcoholism, clinical and experimental research2018
Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.
Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms.Drug and alcohol dependence · 2025Article
- A triple serine motif in the intracellular domain of SorCS2 impacts its cellular signaling.iScience · 2025Article
- Alterations in Neurotrophins in Alcohol-Addicted Patients during Alcohol Withdrawal.Brain sciences · 2024Review
- Polygenic influences on the behavioral effects of alcohol withdrawal in a mixed-ancestry population from the collaborative study on the genetics of alcoholism (COGA).Molecular and cellular neurosciences · 2023Article
- Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks.Cellular and molecular neurobiology · 2023Article
- Alcohol withdrawal in past-year drinkers with unhealthy alcohol use: Prevalence, characteristics, and correlates in a national epidemiologic survey.Alcoholism, clinical and experimental research · 2022Article
- Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice.Translational psychiatry · 2021Article
- Genetic and Pharmacological Manipulations of Glyoxalase 1 Mediate Ethanol Withdrawal Seizure Susceptibility in Mice.Brain sciences · 2021Article
- Common Factors Underlying Diverse Responses in Alcohol Use Disorder.Psychiatric research and clinical practice · 2021Article
- Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse.Biological psychiatry · 2020Review
- Reduced Alcohol Seeking and Withdrawal Symptoms in Mice Lacking the BDNF Receptor SorCS2.Frontiers in pharmacology · 2019Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundEfforts to promote the cessation of harmful alcohol use are hindered by the affective and physiological components of alcohol withdrawal (AW), which can include life-threatening seizures. Although previous studies of AW and relapse have highlighted the detrimental role of stress, little is known about genetic risk factors.
methodsWe conducted a genome-wide association study of AW symptom count in uniformly assessed subjects with histories of serious AW, followed by additional genotyping in independent AW subjects.
resultsThe top association signal for AW severity was in sortilin family neurotrophin receptor gene SORCS2 on chromosome 4 (European American meta-analysis n = 1,478, p = 4.3 × 10
conclusionsTaken together, these findings indicate that the pathophysiology of withdrawal may involve the effects of stress hormones on neurotrophic factor signaling. Further investigation of these pathways could produce new approaches to managing the aversive consequences of abrupt alcohol cessation.
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Registered trials
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