ArticlePloS one2018
Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Cognitive Outcomes After Hip Fracture Surgery: The Association of Postoperative Delirium on Previously Cognitively Normal Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Trial
- Effects of Ramelteon on the Prevention of Postoperative Delirium in Older Patients Undergoing Orthopedic Surgery: The RECOVER Randomized Controlled Trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Effect of baseline cognitive impairment on association between predicted propofol effect site concentration and Bispectral index or sedation score.BMC anesthesiology · 2020Trial
- Turning as a single and dual task-associations with Alzheimer's and vascular pathologies in cognitively healthy older people.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- β-amyloid and β-amyloid precursor protein synthesis and processing: effects of exercise and exercise-related injury.Frontiers in cellular neuroscience · 2026Review
- Association between falls and dementia risk: Evidence from three cohort studies.Journal of translational internal medicine · 2025Article
- Risk of Dementia Diagnosis After Injurious Falls in Older Adults.JAMA network open · 2024Article
- Mobility and associations with levels of cerebrospinal fluid amyloid β and tau in a memory clinic cohort.Frontiers in aging neuroscience · 2023Article
- Association of Depressive Symptoms With Postoperative Delirium and CSF Biomarkers for Alzheimer's Disease Among Hip Fracture Patients.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Article
- Rethinking Fragility Fractures in Type 2 Diabetes: The Link between Hyperinsulinaemia and Osteofragilitas.Biomedicines · 2021Review
- Association of Subjective Cognitive Decline With Postoperative Complications Could Herald Dementia Risk.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Article
- The Effects of Tau, Amyloid, and White Matter Lesions on Mobility, Dual Tasking, and Balance in Older People.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Developing Treatments for Alzheimer's and Related Disorders with Precision Medicine: A Vision.Advances in experimental medicine and biology · 2021Article
- Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- The origin and nature of the complex autoantibody profile in cerebrospinal fluid.Brain, behavior, & immunity - health · 2020Article
- Improving Identification of Cognitive Impairment in Fragility Fracture Patients: Impact of Educational Guidelines on Current Practice.Geriatric orthopaedic surgery & rehabilitation · 2020Article
- Pre-Existing Disability and Its Risk of Fragility Hip Fracture in Older Adults.International journal of environmental research and public health · 2019Article
- Detection of early-stage Alzheimer's pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients.PloS one · 2019Article
- Correction: Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia.PloS one · 2018Article
- Preoperative Neurofilament Light Associated With Postoperative Delirium in Hip Fracture Repair Patients Without Dementia.Journal of the Academy of Consultation-Liaison PsychiatryArticle
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
backgroundThere is strong association of Alzheimer's disease (AD) pathology with gait disorder and falls in older adults without dementia. The goal of the study was to examine the prevalence and severity of AD pathology in older adults without dementia who fall and sustain hip fracture.
methodsCerebrospinal fluid (CSF) was obtained from 168 hip fracture patients. CSF Aβ42/40 ratio, p-tau, and t-tau measures were dichotomized into normal vs. abnormal, and categorized according to the A/T/N classification.
resultsAmong the hip fracture patients, 88.6% of the cognitively normal (Clinical Dementia Rating-CDR 0; n = 70) and 98.8% with mild cognitive impairment (CDR 0.5; n = 81) fell in the abnormal biomarker categories by the A/T/N classification.
conclusionsA large proportion of older hip fracture patients have CSF evidence of AD pathology. Preoperative determination of AD biomarkers may play a crucial role in identifying persons without dementia who have underlying AD pathology in perioperative settings.
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