ArticleGut microbes2019
Impact of early-life events on the susceptibility to Clostridium difficile colonisation and infection in the offspring of the pig.
Article in Gut microbes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Amino acid metabolism by pig intestinal bacteria and consequences for intestinal health and environment: current knowledge and future directions.Journal of animal science and biotechnology · 2026Review
- Characterization of fungal communities transmitted from sow to piglet.Microbiology spectrum · 2025Article
- Fibre composition in sow diets influences bile acid profile in colostrum and in intestinal digesta of their new-born suckling piglets.Journal of nutritional science · 2025Article
- Familiarity, age, weaning and health status impact social proximity networks in dairy calves.Scientific reports · 2023Article
- Environmentally AcquiredBiomedicines · 2022Article
- Fiber Composition in Sows' Diets Modifies Clostridioides difficile Colonization in Their Offspring.Current microbiology · 2022Article
- Porcine and Chicken Intestinal Epithelial Cell Models for Screening Phytogenic Feed Additives-Chances and Limitations in Use as Alternatives to Feeding Trials.Microorganisms · 2022Review
- Diagnostic Methods ofAntibiotics (Basel, Switzerland) · 2021Article
- Editorial for the Special Issue:Microorganisms · 2021Article
- Porcine Colostrum Protects the IPEC-J2 Cells and Piglet Colon Epithelium againstMicroorganisms · 2020Article
- Developing Gut Microbiota Exerts Colonisation Resistance toMicroorganisms · 2019Article
- Gut microbiota features associated with Clostridioides difficile colonization in puppies.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Clostridium difficile has been documented as a major cause of uncontrolled outbreaks of enteritis in neonatal pigs and antibiotic-associated infections in clinical settings. It belongs to the natural cohort of early colonisers of the gastrointestinal tract of pigs and can be detected in faeces up to two weeks post-partum. In older pigs, it often remains under the detection limit. Most neonatal pigs show no clinical signs of disease although C. difficile and its toxins can be detected at high levels in faeces. Increased mortality rates associated with C. difficile on pig farms are, so far, considered "spontaneous" and the predisposing factors are mostly not defined. The infection caused by C. difficile is multifactorial and it is likely that the repertoire of maternal factors, host physiology, the individually developing gut microbiota, co-infections and environmental stress define the conditions for disease development. In this addendum to our recently published work on CDI in neonatal piglets, we discuss the "early-life events" that influence C. difficile spread and infection in neonatal piglets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.